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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 7 of 7 (0.045 seconds)Spelling suggestions: "subject:"pregnenolone"" "subject:"allopregnanolone""
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Allopregnanolone and mood : studies of postmenopausal women during treatment with progesterone /Andréen, Lotta, January 2006 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2006. / Härtill 4 uppsatser.
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| 2 |
Tolerance and antagonism to allopregnanolone effects in the rat CNS /Türkmen, Şahruh, January 2006 (has links)
Diss. (sammanfattning) Umeå : Univ., 2006. / Härtill 4 uppsatser.
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| 3 |
Investigation of two Interacting Neurosteroid Sites on a GABA Receptor by Mutagenesis and Mathematical ModelingHorn, Lindsay A. January 2012 (has links)
No description available.
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| 4 |
Neuroactive steroids and rat CNS /Birzniece, Vita, January 2004 (has links)
Diss. (sammanfattning) Umeå : Univ., 2004. / Härtill 5 uppsatser.
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| 5 |
Vliv neurosteroidů na aktivitu neuronální sítě in vitro. / Neurosteroid effects on neuronal network activity in vitro.Strnadová, Lenka January 2021 (has links)
GABA receptors type A (GABAAR) are ligand-gated ion channels permeable for chloride anions. In the mammalian brain they mediate most of the inhibitory transmission. Moreover, the dysfunctions of the GABA-mediated system result in many neurological disorders, including epilepsy, anxiety and depression. Neurosteroids are cholesterol metabolites interacting with a variety of membrane receptors and have a direct effect on neuronal excitability. The neurosteroids allo-pregnanolone (allo-PA) and pregnanolone (PA) are potent positive modulators of the GABAAR. The goal of this work is to establish a newly constructed application system and a calcium imaging method using the GCaMP sensor to examine the effects of PA on the activity of primary hippocampal cultures. In this work we validate the application system and test the GCaMP calcium sensor in vitro. Application of PA inhibited the spontaneous calcium peaks, which agrees with its known actions on the GABAAR. We discovered that the neurosteroid inhibitory effect on the neuronal network activity changes after repeated applications. The results suggest that there might be some compensatory actions on the GABAAR level during prolonged or repeated exposition to PA. Key words: GABAAR; neurosteroid; pregnanolone; allopregnanolone; calcium; GCaMP; inhibition
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Ring A-reduced progesterone metabolites : potential link between pain and depression and measurement of physiological concentrationsOcvirk, Rok. January 2007 (has links)
No description available.
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| 7 |
Progesterone metabolites learning, tolerance, antagonism & metabolism /Öfverman, Charlotte, January 2009 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2009. / Härtill 5 uppsatser. Även tryckt utgåva.
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