This dissertation presents a comprehensive and comparative progress in sequencing approaches of mixed-model just-in-time (JIT) sequencing problem together with discrete apportioment problem (DAP). The goal of JIT sequencing problem (JITSP) is to keep the rate of usage of parts as constant as possible along the assembly lines, and the goal of DAP is to divide a given integer number of delegates proportionally among the states or the parties according to their population or votes. Furthermore, the supply chain logistics problem is also reported in here with some real life applications.The single-level JITSP, known as the product rate variation problem (PRVP), is pseudo-polynomially solvable. The total PRVP minimizes sum deviation and the bottleneck PRVP minimizes the maximum deviation between the actual production and the ideal production. The assignment approach solves total PRVP whereas the perfect matching works for bottleneck PRVP solving the problem in pseudo-polynomial time. The multi-level JITSP, known as the output rate variation problem (ORVP), is NP-hard in most of the cases. However, some sequencing heuristics and dynamic programming are devised for near optimal solutions. And the pegging assumption reduces the ORVP into weighted case of PRVP. In this dissertation, the total PRVP with square and absolute deviations are considered and mean-based divisor methods are devised for the equitably efficient solution. The simultaneous dealing to the PRVP and DAP establishes the interlink between the production sequencing problem and integer seat allocating problem. The new upper bottlenecks are investigated and the problems are solved comparatively. The bottleneck PRVP instances for small deviations and cyclic sequences for total PRVP are shown to be optimal. The bicriterion sequencing is discussed with Pareto optimal solutions.The production sequencing problem is simultaneously dealt with supply chain logistics to balance overall supply chain system. The cross-docking supply chain logistics problem is formulated with a proposition to be solved. The real-world applications of JITSP and supply chain are listed and some open problems are pointed out as the closing of the dissertation.