Proefschrift Universiteit van Amsterdam. / Met samenvatting in het Nederlands.

Proefschrift Maastricht.

Thesis (doctoral)--University of Lund, 1983. / Includes bibliographical references.

The thesis explores the canine oral cavity, namely, the teeth and the most common dental diseases. Dental injury and disease in dogs is a topic of growing interest in veterinary science. The theoretical section discusses the anatomy of the head, oral cavity and teeth. It presents general knowledge of veterinary dentistry and a list of the most common oral cavity diseases. The practical section explores the suitability and the effectiveness of two prevention methods against the build-up of dental plaque, respectively, against the spread of periodontitis. Diseases affecting the periodontium are increasingly common in dogs; they are deemed to be the most frequent diseases affecting small animals above five years of age. There are two most common periodontal diseases. The first, gingivitis, is a reversible inflammation of the gum. The second, periodontitis, is essentially irreversible without specialized treatment and often leads to loss of teeth. The major criterion for maintaining a healthy oral cavity is prevention. Therefore, two methods of home-based prevention are compared in the practical part of the thesis. First, all patients underwent a full-scale dental treatment in a veterinary centre, that is, a comprehensive ultrasonic cleaning and polishing with dental cleaning paste. Then, ascophyllum nodosum, a seaweed also known as Norwegian kelp, was mixed within the daily food ration of half of the patients. In this way, the teeth were being cleaned passively. The second half of the patients had their teeth cleaned with Orozyme, an enzyme-formula oral hygiene gel for dogs, and this way an active teeth cleaning method was explored. Six weeks after the initial dental treatment, a dental plaque identification test was carried out in a veterinary centre. Statistical analysis of the resulting data did not signal substantial differences between the treatment with Norwegian kelp and that of using the oral gel. A combination of the two techniques is, therefore, recommended as the best prevention strategy against plaque build-up.

Mainz, Universität, Habilitation.

The theoretical part of the thesis deals with the problems of imported infectious diseases. It comprises the factors influencing their incidence and the possibilities of specific and nonspecific prophylaxis and prevention. Further on, this part focuses on chosen infectious diseases, their epidemiological and clinical characteristics and trends in incidence. These infections are divided according to possibilities of specific prophylaxis. The thesis offers an overview of the possibilities of pre-travel consultancy in the South Bohemia region. The practical part of the thesis aims at the characterization of the incidence of imported infectious diseases in the districts within the region of South Bohemia in the years 2000 ? 2010. It also presents a survey of medical facilities and other subjects providing pre-travel consultancy and specific prophylaxis in the sphere of imported infectious diseases prevention. During the monitoring period, the total number of imported diseases which occurred in the region of South Bohemia and were registered in the EPIDAT system was 351. Out of this number, 205 cases occurred in the district of České Budějovice. (Český Krumlov ? 47, Jindřichův Hradec ? 25, Písek ? 2, Prachatice ? 17, Strakonice ? 31, Tábor ? 24). The most frequent imported infections were alimentary infections (240 cases, i.e.68 %); out of this, the most frequent cases were diseases caused by Salmonella (73 cases), Shigella (71 cases) and campylobacters (42 cases). The most frequent countries of origin were Egypt (43 cases), Croatia (42 cases) and India (30 cases). The number of medical facilities and other subjects providing pre-travelling consultancy and specific prophylaxis of infectious diseases rose from nine to thirteen during the period of monitoring. Four hypotheses were determined within this thesis. Hypothesis no.1 ? during the period of monitoring the total number of imported infectious diseases increased. Hypothesis no.2 ? during the period of monitoring the total number of infectious diseases imported from exotic destinations increased. Hypothesis no. 3 ? during the period of monitoring there was an increase in the number of the facilities and other subjects providing pre-travel advice, vaccination or other specific prophylaxis. Hypothesis no. 4 ? the increasing number of medical facilities or other subjects providing pre-travel advice, vaccination or other specific prophylaxis did not influence an increase in the number of imported infectious diseases during the period of monitoring. Only hypotheses no. 3 and no. 4 were proved.

Objective Our aim was to compare two regimens of antibiotic prophylaxis at the time of repair of obstetric anal sphincter injury. Benefit of long regimen of antibiotic prophylaxis in comparison with short regimen of antibiotic administration haven't been till now proven. Material and Methods Women who gave vaginal birth in department of gynaecology and obstetrics of the First Faculty of Medicine of Charles University and Hospital Bulovka from 1.1.2008 to 30.6.2013 and who sustained third - or fourth - degree perineal tears have been enrolled in our trial. All women who fulfilled trial criteria received at the time of repair antibiotic prophylaxis which was cefuroxim (second - generation cephalosporin). This antibiotic has good sensitivity to vaginal gram-positive flora and to rectal gram-negative microorganisms too. Suture technique and following postpartum care have been standardized. All enrolled women were checked 2 weeks and 3 months after delivery. We evaluated subjective and objective parameters of healing of the obstetric perineal injury and 3 months postpartum we looked for symptomps regarding anal incontinence. The Manchester questionnaire was used for evaluation of anal incontince occurance. Results Incidence of third - and fourth - degree perineal tears was 1,4 % during period of our...

At present time of modern worldwide tourism using air transport, the risk of spreading an infectious disease in the Czech Republic cannot be underestimated. Air transport has become quite common way of travelling for Czech citizens so the travel time has shortened significantly. From this viewpoint Czech residents are at potential hazard of highly infectious diseases (HID). This Diploma thesis deals with biological agents which are divided into four risk groups on the basis of patogenes, a hazard to the staff and possible treatment and prophylaxis. Each of the groups requires different level of protection against the infection and its spread. The groups are graded from 1 to 4, i.e. BSL-1, BSL-2, BSL{--}3 and BSL{--}4. Biosafety level 4 (BSL-4) poses a high individual risk of life-threatening diseases where no prevention and treatment are available. This group includes various viral hemorrhanic fevers (VHF) accompanied by heavy tissue bleeding which can be caused by philoviruses, arenaviruses, buniaviruses and flaviviruses. These virus families include viruses like Ebola, Marburg, Lassa, Junin (Argentine VHF), Machupo (Bolivian VHF), Sabia (Brazilian VHF), Guanarito (Venezuelan VHF), Rift Halley fever, Hanta virus, Variola virus, Severe Acute Respiratory Syndrome (SARS) and others. Even the hazard of BSL-3 biological agents with, in history well-known, Bacillus anthracis should not be ignored. The hazard of highly infectious diseases (HID) related to tourism consists in the incubation period. Tourists are infected during their stay abroad and on their way back to the Czech Republic the disease is highly developed. The HID transmission to other people confined in the space of the plane is then very simple. The attention is also paid to the pandemic (H1N1) 2009 influenza virus which showed the possible ways of infection identification and population protection in the Czech Republic together with all subsequent effects.

Objective Our aim was to compare two regimens of antibiotic prophylaxis at the time of repair of obstetric anal sphincter injury. Benefit of long regimen of antibiotic prophylaxis in comparison with short regimen of antibiotic administration haven't been till now proven. Material and Methods Women who gave vaginal birth in department of gynaecology and obstetrics of the First Faculty of Medicine of Charles University and Hospital Bulovka from 1.1.2008 to 30.6.2013 and who sustained third - or fourth - degree perineal tears have been enrolled in our trial. All women who fulfilled trial criteria received at the time of repair antibiotic prophylaxis which was cefuroxim (second - generation cephalosporin). This antibiotic has good sensitivity to vaginal gram-positive flora and to rectal gram-negative microorganisms too. Suture technique and following postpartum care have been standardized. All enrolled women were checked 2 weeks and 3 months after delivery. We evaluated subjective and objective parameters of healing of the obstetric perineal injury and 3 months postpartum we looked for symptomps regarding anal incontinence. The Manchester questionnaire was used for evaluation of anal incontince occurance. Results Incidence of third - and fourth - degree perineal tears was 1,4 % during period of our...

1 PURPOSE OF THE STUDY Heterotopic ossification is frequent and well known complication after primary total hip arthroplasty. Prophylaxis is crucial, ohterwise when ossification is matured, the only treatment option is surgical removal during revision hip surgery. Prophylaxis options are pre, peri- and postoperative modalities. Effectiveness of the profylaxis step sis the aim of this disertation. The goal of Study 1 was to prove the positive side effect of tranexamic acid application to reduce the heterotopic ossification ratio after elective total hip replacement. The goal of Study 2 was to prove the reduction in HO ratio with experimental modification of anterolateral approach with electrosurgery. The goal of Study 3 was to detect the knowledge among czech orthopaedic surgeons in ossification issues and compare the results of questionnaire with german results. 2 MATERIAL AND METHODS Study 1 Cohort of 401 total hip replacements were assessed prospectivelly. Stratification of particular degrees in Brooker scale, sex, laterality and fixation type were evaluated. The average follow up was 6,10 year (40m to 113m). Hips from 2012 are referential and hips from 2016 are administered to tranexamic acid procotol. Other secondary prophylactic modalities (farmacoprophylaxy or radiotherapy), tertiary...