This study analyzed the malaria situation in 21 malaria endemic countries in the region of the Americas to assess progress towards achieving Roll Back Malaria objectives (RBM) and Millennium Development Goals (MDGs). The study analyzed data from the years 2000 and 2005, which also highlighted various interventions that were underway to improve the malaria situation in the region during this period. Data from the year 2000 were used as a baseline both for RBM objectives as well as for MDGs. Findings of the study indicated the region of the Americas has made progress toward reducing the burden of malaria as a public health burden and this itself is a reflection of progress towards achieving the two global targets. Outcomes of the study also revealed some programmatic strength that might help the region to embark on a more comprehensive, interdisciplinary malaria elimination strategy in the majority of the region’s countries.