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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Influence of Recombination C1-Inhibitor on proliferation and migration of Human Breast Cancer Cells

Ye, Chi-xin 02 September 2010 (has links)
Human C1 inhibitor (C1 INH) belongs to the superfamily of serine protease inhibitors (serpins). It is the only known physiological inhibitor of C1s and C1r, therefore C1 INH plays an essential role as a regulator of complement classical pathway. C1 INH is also one of the major inhibitors of plasma kallikrein and activated factor XII of the kinin system. There is evidence that C1 INH can also inhibit the complement lectin pathway proteases, and the complement alternative pathway (C3b), plasminogen activator, activated factor XI, and kallikrein. A recent report indicated C1 inhibitor was significantly down-regulated in normal breast cells compared to malignant cell line. Thus, the major aim of this project is to study the effect of recombinant C1 inhibitor Ile379-Ala478 on human breast cancer cells. In this study, we constructed plasmid containing DNA fragment for C1 inhibitor C-terminal negion of Ile379-Ala478. Then the constructed plasmid was transferred into E.coli BL21(DE3) for expression. The recombinant protein was purifed by GST-affinity chromatography. Recombinant C1 inhibitor produced by E.coli was used to treat breast cancer cells (MDA MB 435s) to study its effect on cell proliferation and migration. Results showed that recombinant C1 inhibitor Ile379-Ala478 protein inhibited proliferation of MDA MB 435s cells after four, six or eight days, incubation in the presence of recombinant protein (1~100 nM). However, cell migration was inhibited only at 100 nM on 48 hrurs incubation..Our experimental data showed that the recombinant C1 inhibitor Ile379-Ala478 inhibited proliferation and migration of MDA MB 435s cells.

Das konservierte Zellproliferationsgen CDC123 kodiert für einen Initiationsfaktor der Translation: 2gamma-AP

Richter, Frank, January 2006 (has links)
Stuttgart, Universiẗat, Diss., 2006.

Bedeutung des Proliferationsmarkers MIB-1 für die individuelle Überlebenszeitprognose bei Patienten mit Mundhöhlenkarzinomen

Rohleder, Sandra Elna, January 2006 (has links)
Tübingen, Universiẗat, Diss., 2006.

Der Einfluss von Thrombin, Faktor XIII, kälteunlöslichem Globulin und von Kallikrein auf die Fibroblastenproliferation

Söchting, Andreas, January 1983 (has links)
Thesis (doctoral)--Kiel, 1983.

Dynamics of chromosome instability in human cells undergoing immortalization

Deng, Wen, 鄧文 January 2005 (has links)
published_or_final_version / abstract / Anatomy / Doctoral / Doctor of Philosophy

The role of mRNA stability and Fos protein in transient c-fos mRNA accumulation

Wilson, Timothy Craig January 1988 (has links)
No description available.

The regulation of cyclooxygenase 2, cPLA←2 and lipocortin 1 by IL-1B in A549 cells

Newman, Simon Paul January 1996 (has links)
No description available.

The stability of the plasmid pJDB248 in chemostat culture of Saccharomyces cerevisiae

Braley, Richard January 1995 (has links)
No description available.

Control of mitotic exit in Saccharomyces cerevisiae

Lee, Sarah Elizabeth January 2001 (has links)
No description available.

Protein:DNA interactions at yeast replication origins in vivo

Cocker, Julie Hazel January 1995 (has links)
No description available.

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