Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 5 uppsatser.

No description available.

Thesis (Ph. D.)--University of Iowa, 2007. / Supervisor: Elizabeth A. Chrischilles. Includes bibliographical references (leaves 272-282).

We sought increased understanding of men's decision-making process for prostate-specific antigen (PSA) screening, especially among elderly men, and a more knowledgeable basis for interventions to modify screening rates. A cross-sectional postal questionnaire assessed measures consistent with the Theory of Planned Behavior among a population-based age-stratified random sample of 452 Iowa men who were free of prostate cancer and aware of PSA. Our primary outcome was intention to receive PSA screening within a year; this encompassed the degree men wanted and planned to be screened. We examined three explanatory variables via structural equation modeling: attitude, social influence, and perceived control. Attitude included the degree screening is important-unnecessary, reassuring-worrisome, and useful-useless. Social influence encompassed the extent a man believed people expect him to, and think he should be screened. Perceived control covered the degree a man can be screened, if desired, and how much control he has over screening. We then examined attitude, social influence, and perceived control as dependent variables. We examined how potential outcomes of screening influenced attitude, how specific people affected overall social influence, and how specific factors influenced perceived control. Roughly 75% expressed intent to receive PSA screening within a year. Attitude, social influence, and perceived control each contributed significantly to the explanation of intentions (p<0.001); the model accounted for 72% of the variability in intention. Detecting cancer early, obtaining peace of mind, knowing their PSA value, and false test results were potential outcomes and each convincingly influenced attitude. A man's wife, primary care physician, urologist, family, friends, and people with cancer each visibly swayed overall perceived social influence. The impacts of health insurance, transportation, information, health problems, including PSA in routine exams, and primary care physicians on perceived control was less clear. Elderly men were unaware of the PSA controversy and believed physicians recommend screening men their age. Our results suggest potential strategies to modify screening rates that include messages to modify men's attitudes about PSA screening and messages that target socially influential people. Being uninformed appears to be an important problem among elderly men who receive PSA screening.

Thesis (Ph. D.)--Rutgers University, 2008. / "Graduate Program in Medicinal Chemistry." Includes bibliographical references (p. 156-174).

>Magister Scientiae - MSc / Prostate cancer is a deadly disease that occurs in the male’s prostate gland. A prostate gland is a walnut structure that forms part of the male’s reproductive system. Prostate cancer is caused by high level than normal of PSA (Gleason score > 4 ng ml-1) in human blood. Some symptoms associated with high levels of PSA include blood in urine, pain when urinating, difficulty in getting and keeping an erection, blood in semen and pain in upper thigh. An immunosensor is a type of biosensor that has an antigen or antibody fragment as its biological recognition component. The specificity of the molecular recognition of antigen by antibodies to form a stable complex is the basis of immunosensor technology. In this work, overoxidized polypyrrole (OvoxPpy) was electrosynthesized as a novel sensor platform on glassy carbon electrode (GCE). The OvoxPpy was then doped with osmium telluride quantum dots(OsTe2QDs) by drop-coating method to form OsTe2QDs|OvoxPpy|GCE system. The morphology and the size of OsTe2QDs|OvoxPpy|GCE nanocomposite were determined using scanning electron microscopy. The size of thioglycolic acid capped osmium telluride quantum dots (TGA-OsTe2QDs) used as support material for the biosensor was about 2.289 nm. These quantum dots showed an excellent photo-absorption properties with an ultraviolet- visible (UV-Vis) photo absortion band occurring at 406nm associated with high band energy of 3.05 eV. The electrochemical immunosensor for PSA was prepared by immobilizing anti- PSA-antibody onto the OsTe2QDs|OvoxPpy|GCE by drop-coating and allowing it to dry for 2h. The nanocomposite sensor platform and the immunosensor were electrochemically characterised by voltammetric and impedimetric techniques. The phase shift in Bode diagram at maximum frequency was indicative of kinetic changes. Charge transfer resistance, Rct, was used as the analytical parameter for measuring the interfacial kinetics which occurred as a result of the bio-recognition event between anti-PSA-antibody and PSA. The impedance of the quantum dot electrode (TGA-OsTe2QDs-Nafion|GCE) was lower (1.490 x 104 kΩ) than the impedance of the immunosensor platform (BSA-Anti-PSA-antibody|TGA-OsTe2 QDs|OvoxPpy|GCE), 2.754 x 104. The Rct of the immunosensor was found to increase with increasing concentration of PSA. The linearity of the immunosensor at the very low concentration range (1.266 - 4.207 fg ml-1) tested, confirms its high sensitivity for PSA.

No description available.

Thesis (Ph.D.)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Pharmaceutics. Title from title-page of electronic thesis. Bibliography: leaves 289-311.

Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2003. / Vita. Includes bibliographical references (leaves 61-69).

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2007. / Härtill 5 uppsatser.