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Host viral protein-protein interaction in influenza A virus infectionAlmutairi, Saeedah 24 July 2013 (has links)
Influenza A virus is well known for its severe clinical consequences. Structurally, this virus is made up of a lipid bilayer embedded with HA, NA and M2 proteins and a core containing eight viral ribonucleoprotein (RNP) complexes. In a typical RNP complex, the nucleoprotein binds with RNA in a non specific manner. The nucleoprotein plays a vital role in transcription, replication, and packaging of RNA during infection. This study aims that NP of A/PR/8/34(H1N1) virus and A/NY/55/2004(H3N2) virus interact with different host proteins depending on cell lines and virus strains. Monoclonal antibodies targeting the nucleoprotein of these viruses have been used for immunoprecipitation and the interacting proteins were identified by mass spectrometry. Tow proteins from the cytoplasm (elongation factor 1 sigma, and Mov10 protein) and 3 proteins from the nucleus (heat shock protein70, hnRNP K protein, and anti alpha actinin 4) were found in all the viral infected cells, and were chosen for validation study. This study will help to understand the virus-host interactions in a better way and may open the gateway for the synthesis of new antiviral drugs which can block these interactions, hence controlling the infection.
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Host viral protein-protein interaction in influenza A virus infectionAlmutairi, Saeedah 24 July 2013 (has links)
Influenza A virus is well known for its severe clinical consequences. Structurally, this virus is made up of a lipid bilayer embedded with HA, NA and M2 proteins and a core containing eight viral ribonucleoprotein (RNP) complexes. In a typical RNP complex, the nucleoprotein binds with RNA in a non specific manner. The nucleoprotein plays a vital role in transcription, replication, and packaging of RNA during infection. This study aims that NP of A/PR/8/34(H1N1) virus and A/NY/55/2004(H3N2) virus interact with different host proteins depending on cell lines and virus strains. Monoclonal antibodies targeting the nucleoprotein of these viruses have been used for immunoprecipitation and the interacting proteins were identified by mass spectrometry. Tow proteins from the cytoplasm (elongation factor 1 sigma, and Mov10 protein) and 3 proteins from the nucleus (heat shock protein70, hnRNP K protein, and anti alpha actinin 4) were found in all the viral infected cells, and were chosen for validation study. This study will help to understand the virus-host interactions in a better way and may open the gateway for the synthesis of new antiviral drugs which can block these interactions, hence controlling the infection.
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Protein interactions and phase behavior in aqueous solutions effects of salt, polymer, and organic additives /Dumetz, Andre C. January 2008 (has links)
Thesis (Ph.D.)--University of Delaware, 2007. / Principal faculty advisor: Abraham M. Lenhoff, Dept. of Chemical Engineering, and Eric W. Kaler, College of Engineering . Includes bibliographical references.
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Adenovirus and its interaction with host cell proteins /Carr, Sharon. January 2007 (has links)
Thesis (M.Phil.) - University of St Andrews, March 2007.
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Protein-Protein interactions involved in the biogenesis of eukaryotic small ribosomal subunitsCastle, Cathy Lynn. January 2008 (has links) (PDF)
Thesis (MS)--Montana State University--Bozeman, 2008. / Typescript. Chairperson, Graduate Committee: Mensur Dlakic. Includes bibliographical references (leaves 95-105).
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Characterization of interactors of the cellular prion proteinBruns, Christopher January 2010 (has links)
München, Techn. Univ., Diss., 2010.
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Identification of protein-protein-interactions in vitro based on high-density protein arraysFaupel, Thomas. January 2004 (has links) (PDF)
Berlin, Techn. Univ., Diss., 2004. / Computerdatei im Fernzugriff.
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Structural mechanism for ordered assembly of box C/D small ribonucleoprotein particlesBrown, Karen Raquel. Li, Hong. January 2005 (has links)
Thesis (M.S.)--Florida State University, 2005. / Advisor: Dr. Hong Li, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Sept. 16, 2005). Document formatted into pages; contains vi, 45 pages. Includes bibliographical references.
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Identification of interactions between SARS-CoV 3a and human host proteins /Yang, Yanzhen. January 2005 (has links)
Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2005. / Includes bibliographical references (leaves 75-88). Also available in electronic version.
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Protein-protein interactions of Arabidopsis homologues of polyadenylation factors Clp1p and Pcfl1pMo, Min. January 2006 (has links)
Thesis (M.S.)--Miami University, Dept. of Botany, 2006. / Title from first page of PDF document. Includes bibliographical references (p. 21-25).
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