The purpose of the present investigation was to compare the psychological factors related to drug use by college athletes on seven drug categories. A questionnaire was given to male and female Division I college athletes asking them about their use of drugs. The frequency, intensity and duration of use/non-use was used to divide subjects into high and low/nonuser categories. Dependent measures included the Profile of Mood States, Coopersmith Self-Esteem Inventory and questions assessing athlete stress. A multivariate analysis of variance(MANOVA) was conducted in a 2 x 2 (alcohol high/low, non-user x male/female) design to distinguish significant differences on the POMS and stress questions followed by univariate ANOVA's. A separate ANOVA was run on Coopersmith's Self-Esteem Inventory. Results indicated that high alcohol users scored significantly higher on anger, fatigue and vigor than low/non-users. Significant differences were found between males and females on the pressure felt from coaches to perform well.