Introduction: This study explored the subjective experience of relapse of psychosis from the patients’ perspective and the meanings they attach to the relapse, their prevention and their perception of risk of relapse. Method: A qualitative methodology was used based on a semi-structure interview. Audio tapes were transcribed verbatim and two researchers participated in a content analysis that identified five major themes: meaning of relapse, perceived risk of relapse in the future, views on antipsychotic medication, subjective risk and protective factors of relapse and the cost of having psychosis. Results: Patients’ view of relapse was similar to those held by psychiatrists, however, patients had a broader definition of the criteria of relapse, extending from family support to medication discontinuation. Their major concerns were the side effects and the independence of antipsychotic medication. Conclusion: Ideas about what constitutes relapse need to take into account the patients’ views and experiences in order to further improve and develop relevant intervention of relapse prevention in early psychosis. / published_or_final_version / Psychological Medicine / Master / Master of Psychological Medicine