The domain of medical imaging analysis has burgeoned in recent years due to the availability and affordability of digital radiographic imaging equipment and associated algorithms and, as such, there has been significant activity in the automation of the medical diagnostic process. One such process, cephalometric analysis, is manually intensive and it can take an experienced orthodontist thirty minutes to analyse one radiology image. This thesis describes an approach, based on genetic programming, neural networks and machine learning, to automate this process. A cephalometric analysis involves locating a number of points in an X-ray and determining the linear and angular relationships between them. If the points can be located accurately enough, the rest of the analysis is straightforward. The investigative steps undertaken were as follows: Firstly, a previously published method, which was claimed to be domain independent, was implemented and tested on a selection of landmarks, ranging from easy to very difficult. These included the menton, upper lip, incisal upper incisor, nose tip and sella landmarks. The method used pixel values, and pixel statistics (mean and standard deviation) of pre-determined regions as inputs to a genetic programming detector. This approach proved unsatisfactory and the second part of the investigation focused on alternative handcrafted features sets and fitness measures. This proved to be much more successful and the third part of the investigation involved using pulse coupled neural networks to replace the handcrafted features with learned ones. The fourth and final stage involved an analysis of the evolved programs to determine whether reasonable algorithms had been evolved and not just random artefacts learnt from the training images. A significant finding from the investigative steps was that the new domain independent approach, using pulse coupled neural networks and genetic programming to evolve programs, was as good as or even better than one using the handcrafted features. The advantage of this finding is that little domain knowledge is required, thus obviating the requirement to manually generate handcrafted features. The investigation revealed that some of the easy landmarks could be found with 100\% accuracy while the accuracy of finding the most difficult ones was around 78\%. An extensive analysis of evolved programs revealed underlying regularities that were captured during the evolutionary process. Even though the evolutionary process took different routes and a diverse range of programs was evolved, many of the programs with an acceptable detection rate implemented algorithms with similar characteristics. The major outcome of this work is that the method described in this thesis could be used as the basis of an automated system. The orthodontist would be required to manually correct a few errors before completing the analysis.

As Redes Neurais Pulsadas são objeto de intensa pesquisa na atualidade. Neste trabalho é avaliado o potencial de aplicação deste paradigma neural, na tarefa de reconhecimento automático do locutor. Após uma revisão dos tópicos considerados importantes para o entendimento do reconhecimento automático do locutor e das redes neurais artificiais, é realizada a implementação e testes do modelo de neurônio com resposta por impulsos. A partir deste modelo é proposta uma nova arquitetura de rede com neurônios pulsados para a implementação de um sistema de reconhecimento automático do locutor. Para a realização dos testes foi utilizada a base de dados Speaker Recognition v1.0, do CSLU – Center for Spoken Language Understanding do Oregon Graduate Institute - E.U.A., contendo frases gravadas a partir de linhas telefônicas digitais. Para a etapa de classificação foi utilizada uma rede neural do tipo perceptron multicamada e os testes foram realizados no modo dependente e independente do texto. A viabilidade das Redes Neurais Pulsadas para o reconhecimento automático do locutor foi constatada, demonstrando que este paradigma neural é promissor para tratar as informações temporais do sinal de voz. / Pulsed Neural Networks have received a lot of attention from researchers. This work aims to verify the capability of this neural paradigm when applied to a speaker recognition task. After a description of the automatic speaker recognition and artificial neural networks fundamentals, a spike response model of neurons is tested. A novel neural network architecture based on this neuron model is proposed and used in a speaker recognition system. Text dependent and independent tests were performed using the Speaker Recognition v1.0 database from CSLU – Center for Spoken Language Understanding of Oregon Graduate Institute - U.S.A. A multilayer perceptron is used as a classifier. The Pulsed Neural Networks demonstrated its capability to deal with temporal information and the use of this neural paradigm in a speaker recognition task is promising.

As Redes Neurais Pulsadas são objeto de intensa pesquisa na atualidade. Neste trabalho é avaliado o potencial de aplicação deste paradigma neural, na tarefa de reconhecimento automático do locutor. Após uma revisão dos tópicos considerados importantes para o entendimento do reconhecimento automático do locutor e das redes neurais artificiais, é realizada a implementação e testes do modelo de neurônio com resposta por impulsos. A partir deste modelo é proposta uma nova arquitetura de rede com neurônios pulsados para a implementação de um sistema de reconhecimento automático do locutor. Para a realização dos testes foi utilizada a base de dados Speaker Recognition v1.0, do CSLU – Center for Spoken Language Understanding do Oregon Graduate Institute - E.U.A., contendo frases gravadas a partir de linhas telefônicas digitais. Para a etapa de classificação foi utilizada uma rede neural do tipo perceptron multicamada e os testes foram realizados no modo dependente e independente do texto. A viabilidade das Redes Neurais Pulsadas para o reconhecimento automático do locutor foi constatada, demonstrando que este paradigma neural é promissor para tratar as informações temporais do sinal de voz. / Pulsed Neural Networks have received a lot of attention from researchers. This work aims to verify the capability of this neural paradigm when applied to a speaker recognition task. After a description of the automatic speaker recognition and artificial neural networks fundamentals, a spike response model of neurons is tested. A novel neural network architecture based on this neuron model is proposed and used in a speaker recognition system. Text dependent and independent tests were performed using the Speaker Recognition v1.0 database from CSLU – Center for Spoken Language Understanding of Oregon Graduate Institute - U.S.A. A multilayer perceptron is used as a classifier. The Pulsed Neural Networks demonstrated its capability to deal with temporal information and the use of this neural paradigm in a speaker recognition task is promising.

<p>This thesis is based on five papers addressing variance reduction in different ways. The papers have in common that they all present new numerical methods.</p><p>Paper I investigates quantitative structure-retention relationships from an image processing perspective, using an artificial neural network to preprocess three-dimensional structural descriptions of the studied steroid molecules.</p><p>Paper II presents a new method for computing free energies. Free energy is the quantity that determines chemical equilibria and partition coefficients. The proposed method may be used for estimating, e.g., chromatographic retention without performing experiments.</p><p>Two papers (III and IV) deal with correcting deviations from bilinearity by so-called peak alignment. Bilinearity is a theoretical assumption about the distribution of instrumental data that is often violated by measured data. Deviations from bilinearity lead to increased variance, both in the data and in inferences from the data, unless invariance to the deviations is built into the model, e.g., by the use of the method proposed in paper III and extended in paper IV.</p><p>Paper V addresses a generic problem in classification; namely, how to measure the goodness of different data representations, so that the best classifier may be constructed. </p><p>Variance reduction is one of the pillars on which analytical chemistry rests. This thesis considers two aspects on variance reduction: before and after experiments are performed. Before experimenting, theoretical predictions of experimental outcomes may be used to direct which experiments to perform, and how to perform them (papers I and II). After experiments are performed, the variance of inferences from the measured data are affected by the method of data analysis (papers III-V).</p>

This thesis is based on five papers addressing variance reduction in different ways. The papers have in common that they all present new numerical methods. Paper I investigates quantitative structure-retention relationships from an image processing perspective, using an artificial neural network to preprocess three-dimensional structural descriptions of the studied steroid molecules. Paper II presents a new method for computing free energies. Free energy is the quantity that determines chemical equilibria and partition coefficients. The proposed method may be used for estimating, e.g., chromatographic retention without performing experiments. Two papers (III and IV) deal with correcting deviations from bilinearity by so-called peak alignment. Bilinearity is a theoretical assumption about the distribution of instrumental data that is often violated by measured data. Deviations from bilinearity lead to increased variance, both in the data and in inferences from the data, unless invariance to the deviations is built into the model, e.g., by the use of the method proposed in paper III and extended in paper IV. Paper V addresses a generic problem in classification; namely, how to measure the goodness of different data representations, so that the best classifier may be constructed. Variance reduction is one of the pillars on which analytical chemistry rests. This thesis considers two aspects on variance reduction: before and after experiments are performed. Before experimenting, theoretical predictions of experimental outcomes may be used to direct which experiments to perform, and how to perform them (papers I and II). After experiments are performed, the variance of inferences from the measured data are affected by the method of data analysis (papers III-V).