This study investigates use of the organosilane 3-(trimethoxysilyl) propyldimethyl octadecyl ammonium chloride (Si-Quat) as a wood treatment to impart residual moisture and organism control on wood substrates. Study 1, which utilized experimental testing procedures to evaluate mold growth after standardized heat treatment, indicated less surface mold on treated samples. Study 2, which utilized standardized testing procedures to evaluate Si-Quat treated wood’s resistance to subterranean termite attack, indicated greater termite mortality and less feeding on treated wood, as well as increased termite feeding preference for untreated wood. Study 3, which utilized standardized testing procedures to evaluate water repellency, indicated significantly reduced moisture gain at higher silane-based treatment levels in comparison to untreated wood. It is concluded that a silane based treatment utilized in this study can be effective for organism control and the possible supplementation to current phytosanitation of wood packaging materials.