Thesis--M. Phil., University of Hong Kong. / Typewritten.

Throughout the 19th and early 20th centuries fluorine was generally considered to be a poison. Scientif articles dealt with its toxic properties when used in preservatives and pesticides, and with the ill-effects of extremely high concentrations of fluoride in drinking water and in industrial processing. About 1942 the beneficial effects of optimum concentrations of fluorine became apparent. It was found that certain communities had water supplies which contained fluorine at a level which tended to reduce dental caries. As a public health procedure other communities began to fluorinate their water to a level which was cansidered optimum for the reduction of dental caries. This level was generally found to be one part per million of fluorine. [...]

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The mammalian FMO represents a multigene family which oxygenates a large number of xenobiotics. No physiological role has been determined for FMO, although synthesis of disulfide bonds and detoxification of dietary chemicals have been suggested. Five FMO gene subfamilies, each containing a single gene, have been identified. In this study, we determined the patterns of fetal and neonatal development of FMO1 and FMO2 in rabbit liver and lung. The expression of two major isoforms, FMO1 and FMO2, in fetal and neonatal animals were characterized at the steady state levels of mRNA. Northern and slot blot analyses were performed with cDNA probes for each isoform to provide a qualitative and quantitative profile. In order to relate developmental changes in FMO to the metabolism of xenobiotics for which lung is a target organ, the developmental expression of lung FMO (FMO2) mRNA is compared to rabbit CYP2B4 and CYP4B1 which are the major constitutive P450s in lung. The results show that the expression of FMO1 and FMO2 is tissue-dependent, although the mechanisms controlling the mRNA expression, such as rate of transcription, processing of primary RNA, efficiencies of nucleocytoplasmic transport and stability of RNA in the cytoplasm, are still unknown. The results indicate that the early development- and tissue-specific expression patterns of mRNA for FMO1 and FMO2 might play a significant role in the target organ toxicity of xenobiotics in the rabbit fetus and neonate. / Graduation date: 1995 / Best scan available. Original is a black and white photocopy.

Thesis (Ph.D.)-- University of Adelaide, Department of Human Physiology and Pharacology, 1980.

Thesis (Ph. D.)--University of Michigan, 1928. / Reprint of an article published in the journal of biological chemistry, vol. LXXXVI, no. 1, March, 1930, under title: The metabolism of sulfur. XVII. The rate of oxidation of ingested cystine in the organism of the rabbit. By Genevieve Stearns and Howard B. Lewis. Bibliography: p. 105.