181 |
Clinical symptoms and volumetric radiological responses of acoustic neuroma patients, treated with hypo-fractionated image guided radiotherapy (IGRT) at Groote Schuur hospital between 2013 and 2016Riddick, Alison 17 May 2019 (has links)
Background:
Stereotactic radiosurgery (SRS) is the gold standard for treatment of small and medium
sized tumours, although fractionated regimens are well described. Access is limited in
resource-constrained settings. There are no South African data describing outcomes of AN
patients treated with fractionated stereotactic radiotherapy (SRT) using photons. We
describe clinical and radiological outcomes of AN patients treated with SRT at an academic
centre in Cape Town, South Africa.
Objectives:
To describe patient demographics, tumour characteristics and patients’ symptoms and
changes in symptoms at follow-up. To investigate tumour local control (LC) rates at last
follow up MRI, and compare LC rates described for SRS in the literature. To correlate
radiologists’ serial 2D maximum linear diameter (MLD) measurements with calculated 3D
tumour volume (TV).
Methods:
Fifteen AN patients treated with modified SRT (18.0gy/3fractions, were identified from the
planning database; 13 were included. Patient data and tumour characteristics (size, laterality
and previous surgery) were retrospectively extracted from clinic folders. Initial planning data
was accessed and checked. Tumour volumes were contoured by the author on all
subsequent MRI’s per patient and validated by a second investigator; tumour volume (TV)
was automatically calculated. Radiologist’s 2D MLDs were compared with 3D TV. Sensitivity
and specificity of radiologist reported change of MLD as a measure of actual change in TV
was calculated. LC was calculated, from time of treatment to time of last MRI or time of
progression (defined as ≥20% increase in TV).
Results:
Mean age was 60.4years (range 45-79years), with 4 (30.8%) being female. Seven patients
(53.8%) had left sided tumours and median tumour size was 1.15cm3 (mean 1.59 cm3; range
0.62-3.35 cm3). Nine patients (69.2%) had Koos stage 2 ANs, 3 (23.1%) had stage 3
tumours and 1 (7.7%) had a stage I tumour. Two patients had NF2.Median follow-up time
12 was 29 months (range 0-50 months). Median baseline TV, as was 1.15 cm3 (mean 1.59cm3
with range 0.62-3.35 cm3).
Three patients had no follow-up MRIs: 2 demised and 1 declined further follow-up. In total 5
patients died, 4 of unrelated causes and 1 of unknown cause (median time to death after RT
24 months, range 6 - 36 months). LC was 74% at 36months. Hearing preservation rate was
67%. No new facial or trigeminal nerve symptoms were noted. Radiologists correctly
reported tumour growth in 100% of tumours that grew, and specificity was 77.3% in those
that were stable.
Conclusion:
This is the first local study in hypofractionated SRT using photons. We show lower LC rates
than seen in literature; our numbers are small and short follow up time short, with high
attrition rates. Acute treatment toxicities were absent. Longer term follow-up is needed to
assess late RT effects. A prospective study using this method of treatment would better
define LC.
|
182 |
Advanced breast cancer: A retrospective review comparing two palliative radiotherapy protocols used at Groote Schuur Hospital between 2010 and 2013Fakie, Nazia January 2016 (has links)
Purpose: To retrospectively evaluate and compare the loco-regional progression free survival (PFS), overall survival (OS) and acute effects of the two breast palliative regimes used in patients with locally advanced or metastatic breast cancer between 2010 and 2013 in a single institution. Methods: Compliance to treatment, acute skin reactions, progression free and overall survival were retrospectively evaluated in patients who received palliative breast radiotherapy for locally advanced breast cancer between 2010 and 2013. The radiotherapy regimes were either 4Gy per fraction for 5 fractions treated 4 times a week (20Gy) or 6Gy per fraction for 6 fractions treated once a week (36Gy). They may have received previous chemotherapy with minimal or no clinical response, as well as hormonal treatment. Results: Forty three patients were followed up over a median period of 24 months, 14 of which received 20Gy and 29 received 36Gy. The average age was 64 years old. Compliance was 88% in both groups. Both groups had either grade 1 (71% vs 62%), grade 2 (21% vs 24%) or grade 3 (8% vs 14%) acute skin reactions. No grade 4 skin reactions were documented. The PFS was shorter at 4.5 months in the 20Gy group compared to 7.7 months in the 36Gy group (p=0.27). The OS was also shorter at 25.8 months in the 20Gy group compared to 29.6 months in the 36Gy group (p=0.51) Conclusion: This study did not show a statistically significant difference in terms of PFS and OS between the two radiotherapy regimes. They both remain reasonable options in local palliation in patients with locally advanced breast cancer.
|
183 |
A retrospective study of patients with Stage IB2 cervical cancer treated at Groote Schuur Hospital 1993-2008Alleyne-Mike, Kellie January 2013 (has links)
Includes abstract.
Includes bibliographical references.
|
184 |
Image guided radiation therapy applications for head and neck, prostate, and breast cancers using 3D ultrasound imaging and Monte Carlo dose calculationsFraser, Danielle January 2010 (has links)
No description available.
|
185 |
Particle size determination for alpha-emitters using CR-39Hegyi, Gyorgy. January 1999 (has links)
No description available.
|
186 |
Dosimetry of very small photon fieldsPaskalev, Kamen A. January 2002 (has links)
No description available.
|
187 |
Implementation of Monte Carlo treatment planning for lung cancer patientsAl-Yahya, Khalid S. January 2002 (has links)
No description available.
|
188 |
Development of a fast Monte Carlo code for dose calculation in a treatment planning and feasibility study of high contrast portal imagingJabbari Najafabadi, Keivan January 2009 (has links)
No description available.
|
189 |
The use of computed tomography images in Monte Carlo treatment planningBazalova, Magdalena January 2009 (has links)
No description available.
|
190 |
Kinetic theory of irreversible processes in a system of radiation and matterMao, Kefei January 1993 (has links)
No description available.
|
Page generated in 0.0807 seconds