The post-Cold War era saw the extraordinary expansion of UN activity in the maintenance of global peace and security. Such a rapid expansion led to organizational over-stretch and failure and many in the international community began searching for ways to improve UN peacekeeping by reducing deployment time. In the mid-1990s, the Dutch, Canadian and Danish governments released proposals for a UN rapid reaction capability. Unfortunately, of the three proposals only the Danish proposed Stand-by High Readiness Brigade (SHIRBRIG) was implemented. The lack of movement toward UN rapid reaction is due to a number of factors, namely the loss of post-Cold War idealism, a disconnection with the political reality of the time and cost concerns. More fundamentally, rapid reaction posed a threat to state primacy. / October 2006

The post-Cold War era saw the extraordinary expansion of UN activity in the maintenance of global peace and security. Such a rapid expansion led to organizational over-stretch and failure and many in the international community began searching for ways to improve UN peacekeeping by reducing deployment time. In the mid-1990s, the Dutch, Canadian and Danish governments released proposals for a UN rapid reaction capability. Unfortunately, of the three proposals only the Danish proposed Stand-by High Readiness Brigade (SHIRBRIG) was implemented. The lack of movement toward UN rapid reaction is due to a number of factors, namely the loss of post-Cold War idealism, a disconnection with the political reality of the time and cost concerns. More fundamentally, rapid reaction posed a threat to state primacy.

The post-Cold War era saw the extraordinary expansion of UN activity in the maintenance of global peace and security. Such a rapid expansion led to organizational over-stretch and failure and many in the international community began searching for ways to improve UN peacekeeping by reducing deployment time. In the mid-1990s, the Dutch, Canadian and Danish governments released proposals for a UN rapid reaction capability. Unfortunately, of the three proposals only the Danish proposed Stand-by High Readiness Brigade (SHIRBRIG) was implemented. The lack of movement toward UN rapid reaction is due to a number of factors, namely the loss of post-Cold War idealism, a disconnection with the political reality of the time and cost concerns. More fundamentally, rapid reaction posed a threat to state primacy.

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<p>Denna uppsats undersöker om det kan finnas behov att ändra något i grundutbildningen för att de värnpliktiga i svenska flottan skall vara bättre förberedda för att rekryteras till de marina insatsstyrkorna. Det undersöks också huruvida det finns behov att förändra sättet att rekrytera personal till de marina insatsstyrkorna. För att belysa hur väl systemet fungerar som det ser ut idag har en fallstudie på den svenska marina missionen ML i Libanon år 2006-2007 gjorts. Där presenteras erfarenheter från missionen som sedan analyseras med hjälp av delar av det undervisningsmaterial som används under grundutbildningen, GU.</p><p>Av undersökningen har det framkommit att förändringar kan göras i grundutbildningen för att förbereda de värnpliktiga bättre. Ett exempel på förslag som kommit fram är att i större utsträckning implementera internationella reglementen och tillvägagångssätt under grundutbildningen. Förslag på förändringar som kan göras i sättet att rekrytera har också framkommit. Ett exempel på ett sådant förslag är att vid rekrytering testa individens fysiologiska lämplighet likt det sätt som flygvapnet testar sina blivande flygförare.</p> / <p>Basic training to be recruited to the naval rapid reaction forces.</p><p>This paper examines if there might be a need of change in the basic training so that the conscripts in the Swedish navy will be better prepared to be recruited to the naval rapid reaction forces. It also examines if the way to recruit personnel to the naval rapid reaction forces needs to be changed. To show how well the system, as it is today, works, a case study have been made on the Swedish naval mission, ML, in Lebanon during 2006-2007. It presents experiences from the mission that later has been analyzed with the help of parts of the educational material that is used in the basic training.</p><p>By this research it has emerged that changes could be made in the basic training to better prepare the conscripts. One example of the suggestions that has evolved is that to a greater extent involve international regulations and procedures in the basic training. Suggestions to change the way of recruiting personnel has also evolved and one example of such a suggestion is that the recruiting process could include a test where the person’s physiological suitability is being tested. A test similar to the one the Air force let’s you do before becoming a pilot.</p>

Denna uppsats undersöker om det kan finnas behov att ändra något i grundutbildningen för att de värnpliktiga i svenska flottan skall vara bättre förberedda för att rekryteras till de marina insatsstyrkorna. Det undersöks också huruvida det finns behov att förändra sättet att rekrytera personal till de marina insatsstyrkorna. För att belysa hur väl systemet fungerar som det ser ut idag har en fallstudie på den svenska marina missionen ML i Libanon år 2006-2007 gjorts. Där presenteras erfarenheter från missionen som sedan analyseras med hjälp av delar av det undervisningsmaterial som används under grundutbildningen, GU. Av undersökningen har det framkommit att förändringar kan göras i grundutbildningen för att förbereda de värnpliktiga bättre. Ett exempel på förslag som kommit fram är att i större utsträckning implementera internationella reglementen och tillvägagångssätt under grundutbildningen. Förslag på förändringar som kan göras i sättet att rekrytera har också framkommit. Ett exempel på ett sådant förslag är att vid rekrytering testa individens fysiologiska lämplighet likt det sätt som flygvapnet testar sina blivande flygförare. / Basic training to be recruited to the naval rapid reaction forces. This paper examines if there might be a need of change in the basic training so that the conscripts in the Swedish navy will be better prepared to be recruited to the naval rapid reaction forces. It also examines if the way to recruit personnel to the naval rapid reaction forces needs to be changed. To show how well the system, as it is today, works, a case study have been made on the Swedish naval mission, ML, in Lebanon during 2006-2007. It presents experiences from the mission that later has been analyzed with the help of parts of the educational material that is used in the basic training. By this research it has emerged that changes could be made in the basic training to better prepare the conscripts. One example of the suggestions that has evolved is that to a greater extent involve international regulations and procedures in the basic training. Suggestions to change the way of recruiting personnel has also evolved and one example of such a suggestion is that the recruiting process could include a test where the person’s physiological suitability is being tested. A test similar to the one the Air force let’s you do before becoming a pilot.

Natural products are secondary metabolites produced by plants and microorganisms that often possess medicinal properties and are implicated in organismal defense. Drawbacks to utilizing natural products in the pharmaceutical industry are difficulties with isolation from biological sources and low yields that can lack stereospecificity from synthetic sources. It is paramount to solve these issues and to develop novel natural products to combat the growing antimicrobial resistance crisis, which was responsible for ~5 million deaths in 2019 alone. One approach is utilizing enzymes to synthesize existing natural products to improve the yields and stereospecificity issue. This dissertation is focused on the biochemical characterization of three enzymes-ZvFMO, OxaD, and CreE-that are implicated in the detoxification of natural products used for organismal defense or participate in the biosynthesis of novel natural products. Each of these enzymes belong to the flavin-dependent monooxygenase (FMO) family, which catalyze the oxygenation of a substrate, generating an oxidized product. ZvFMO, from the insect food crop pest, Zonocerus variegatus, was determined to catalyze a highly uncoupled oxygenation reaction of the nitrogen or sulfur atom of various substrates. OxaD, from Penicillium oxalicum F30, catalyzes novel sequential oxidation reactions of the indole nitrogen of roquefortine C. CreE, from Streptomyces cremeus, also catalyzes sequential nitrogen oxidation reactions to convert L-aspartate to nitrosuccinate en route to biosynthesis of cremeomycin. For each enzyme, the steady-state kinetics have been determined using an oxygen consumption assay and the rapid-reaction kinetics were measured using anaerobic time-resolved spectroscopy. All three enzymes feature a fast flavin reduction step and a slow flavin dehydration step. The oxygenation chemistry of each enzyme was found to proceed through a highly reactive oxygenating species, the C4a-hydroperoxyflavin. Site-directed mutagenesis efforts led to the identification of key active site residues involved in flavin motion and substrate binding, revealing important information about the active site architecture for enzyme engineering applications and drug discovery efforts. / Doctor of Philosophy / Natural products are compounds that are produced by many plants, fungi, and bacteria that have potent medicinal properties and can be used to defend the organism against pests. Unfortunately, using these compounds widely in the pharmaceutical industry is difficult because it is hard to isolate the compound of interest from the organism that produces it and attempts to produce it chemically can result in low yields. Additionally, the overuse of the current natural products, which are most of the antibiotics on the market today, has led to an extreme increase in the resistance of bacteria, fungi, and parasites to the natural product-based drug. Therefore, it is essential that a method is developed to produce novel natural products at high yields to combat the antimicrobial resistance crisis. One method is by using enzymes to generate the natural products of interest. Enzymes are biological catalysts that speed up reactions by ensuring that less energy is required to transition from a reactant to a product and are highly efficient. This dissertation focuses on the characterization of three enzymes that could aid in our understanding of natural product chemistry. All three enzymes insert an oxygen atom on a nitrogen of their respective reactant. The first enzyme ZvFMO, is from an insect and its reactivity causes the insect to become resistant to the natural product-based plant defense mechanism, demonstrating that ZvFMO is a great candidate for inhibitor design. OxaD is the second enzyme and is involved in producing natural products that have antimicrobial and anticancer properties. The last enzyme, CreE, is involved in generating the natural product, cremeomycin, which possesses potent antimicrobial and anticancer properties as well. The reactions of OxaD and CreE positions these enzymes as candidates to produce novel natural products and other efforts to expand their reactivity. The rates of each reaction step have been determined in this work. Key amino acids that contribute to the reaction chemistry and the uptake of the reactant have been identified, laying a solid foundation for drug discovery efforts.