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Thesis (M.S.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains x, 84 p. : ill. (some col.), maps (part col.). Includes abstract. Includes bibliographical references.

Thesis (Ph. D.)--West Virginia University, 2000. / Title from document title page. Document formatted into pages; contains xv, 166 p. : ill. (some col.), maps (some col.). Includes abstract. Includes bibliographical references.

Thesis (M.S.) -- University of Tennessee, Knoxville, 2006. / Title from title page screen (viewed on Sept. 28, 2006). Thesis advisor: Lisa Muller. Vita. Includes bibliographical references.

Corn oil (CO) and Sterculic foetida oil (SFO) fed rats were injected with [9, 10-methylene-¹⁴C]sterculic acid. Less than 1% of the label was expired as carbon dioxide. The majority of the label was excreted in the urine as short-chain dicarboxylic acids with an intact cyclopropane ring. The major metabolites for both CO and SFO fed rats were cis-3, 4-methylene adipic acid and cis-3, 4- methylene suberic acid. Sterculic acid must undergo β- and [Greek w]-oxidation to form these urinary metabolites, α-oxidation played a minor role in the formation of cis- and trans-3, 4-methylene pimelic acid. Rats on the SFO diet could metabolize sterculic acid faster than fats on the CO diet. However, both CO and SFO fed rats produced the same urinary metabolites. CO fed rats incorporated more label from sterculic acid into protein and acid soluble liver fractions than SFO fed rats. Less than 0.01% of the label from either group was found in liver lipid sterol or glycerol fractions. There was a tendency for SFO fed rats to metabolize n-[1-¹⁴C] octadecane faster than CO fed rats. This suggests that sterculic acid may induce [Greek w]-hydroxylation of n-octadecane. / Graduation date: 1977

The acute phase response induced by bacterial pyrogens, but not by viral pyrogens, has been thoroughly investigated. Polyinosinic:polycytidylic acid (poly I:C) is a synthetic viral pyrogen that is used to simulate viral infection. This dissertation describes how I determined an effective peripheral route and dose of administration of poly I:C to rats. Thereafter I investigated whether poly I:C induced sickness behaviour, and whether repeated administration of poly I:C resulted in the development of tolerance. Intraperitoneal administration of at least 1000μg/kg poly I:C induced fevers in rats, but not sickness behaviour. Unlike repeated administration of LPS, repeated administration of poly I:C in rats did not result in the development of tolerance.

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