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This research has been directed at the study of facilitated oxidation of aliphatic sulfides by neighboring group participation. Mesocyclic polythioether and 2-substituted 6-methylthiobicyclo[2.2.1]heptane derivatives have been examined as model compounds for biological redox reactions. The preparations, structural analogues, and oxidation studies of such compounds have been investigated. A new technique has been developed for the preparation of mesocyclic polythioethers. Conformational analysis, both gas phase and solid state, and quantum mechanical analysis of one- and two-electron oxidation of mesocyclic polythioethers have been undertaken. Crystal and molecular structures of some transition metal complexes of 1,4,7-trithiacyclononane, as well as a number of 2-substituted 6-methylthiobicyclo[2.2.1]heptane derivatives have been determined using single crystal X-ray techniques. Stereoselective oxidation of 2-endo-(hydroxymethyl)-6- endo(methylthio)bicyclo[2.2.1]heptane has been achieved leading to both corresponding diastereomeric sulfoxides.

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Although the psychomotor vigilance task (PVT) is commonly used in adult sleep research, normative data for PVT performance in children have not been published and performance in children with sleep disordered breathing (SDB) has not been explored. This report describes PVT performance among children participating in the Tucson Children's Assessment of Sleep Apnea (TuCASA). A community-based sample of 360 Caucasian and Hispanic children completed a standard PVT trial. Participants were 48% female and 36% Hispanic; mean age was 8.9 years. Children with respiratory disturbance index (RDI) >1 event/hour and those with parent-reported sleep problems were excluded from the normative analysis. Among normal sleepers, performance on several measures improved with increasing age and differed between boys and girls. No ethnic differences were detected. Among children with SDB, no differences in performance were identified. Age and gender differences in PVT performance must be considered when the PVT is utilized in pediatric populations.