Occupational stressors have been extensively studied as predictors of safety performance and employee well-being in previous research. However, many newly introduced organizational constructs that have the characteristics of an occupational stressor have rarely been studied as such, especially from a within-person perspective. The current study focused on three occupational stressors in relation to safety performance. Based on previous literature, I proposed that within individuals, compulsory citizenship behavior, illegitimate tasks, and interpersonal conflict at work as occupational stressors would have negative effects on employees well-being and safety performance through negative emotions (anger), job attitudes (job satisfaction and organizational commitment) and role stressors (role conflict and role ambiguity). In addition, reception of organizational citizenship behavior (ROCB) and perceived safety climate were hypothesized to moderate the relationships of the three occupational stressors with safety performance and employee well-being. Seventy-one nurses were recruited, and data were collected from their survey responses about their daily experiences on the focal variables for 9 shifts over three consecutive working weeks. Results showed that within individuals, the three occupational stressors were positively associated with employee burnout and physical symptoms, and evidence was found that those associations might be mediated by anger, job satisfaction and role conflict. Further, ROCB was found to moderate some of the associations of occupational stressors with safety performance and employee well-being. However, the current study failed to find support for any of the hypotheses regarding perceived safety performance as a moderator in this sample. Findings, limitations and future directions were discussed.