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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 11 to 20 of 513 (0.039 seconds)| 11 |
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cellsMardaryev, A. N., Gdula, M. R., Yarker, J. L., Emelianov, V. N., Poterlowicz, K., Sharov, A. A., Sharova, T. Y., Scarpa, J. A., Chambon, P., Botchkarev, V. A., Fessing, M. Y. January 2014 (has links)
Chromatin structural states and their remodelling, including higher-order chromatin folding and three-dimensional (3D) genome organisation, play an important role in the control of gene expression. The role of 3D genome organisation in the control and execution of lineage-specific transcription programmes during the development and differentiation of multipotent stem cells into specialised cell types remains poorly understood. Here, we show that substantial remodelling of the higher-order chromatin structure of the epidermal differentiation complex (EDC), a keratinocyte lineage-specific gene locus on mouse chromosome 3, occurs during epidermal morphogenesis. During epidermal development, the locus relocates away from the nuclear periphery towards the nuclear interior into a compartment enriched in SC35-positive nuclear speckles. Relocation of the EDC locus occurs prior to the full activation of EDC genes involved in controlling terminal keratinocyte differentiation and is a lineage-specific, developmentally regulated event controlled by transcription factor p63, a master regulator of epidermal development. We also show that, in epidermal progenitor cells, p63 directly regulates the expression of the ATP-dependent chromatin remodeller Brg1, which binds to distinct domains within the EDC and is required for relocation of the EDC towards the nuclear interior. Furthermore, Brg1 also regulates gene expression within the EDC locus during epidermal morphogenesis. Thus, p63 and its direct target Brg1 play an essential role in remodelling the higher-order chromatin structure of the EDC and in the specific positioning of this locus within the landscape of the 3D nuclear space, as required for the efficient expression of EDC genes in epidermal progenitor cells during skin development.
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The Canny Edge Detector RevisitedMcIlhagga, William January 2010 (has links)
No description available.
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Selective synthesis of Neu5Ac2en and its oxazoline derivative using BF3-Et2OMorais, Goreti Ribeiro, Oliveira, Rudi Santiago, Falconer, Robert A. January 2009 (has links)
No description available.
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The influence of profiled sheeting thickness and shear connector's position on strength and ductility of headed shear connectorQureshi, Jawed, Lam, Dennis, Ye, Jianqiao January 2011 (has links)
No description available.
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Effect of shear connector spacing and layout on the shear connector capacity in composite beamsQureshi, Jawed, Lam, Dennis, Ye, Jianqiao January 2011 (has links)
No description available.
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Formation of a hybrid coordination-molecular complexSeaton, Colin C., Scowen, Ian J., Blagden, Nicholas January 2009 (has links)
No description available.
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Structural response of concrete-filled elliptical steel hollow sections under eccentric compressionSheehan, T., Dai, X. H., Chan, T. M., Lam, D. January 2012 (has links)
No description available.
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Investment climate in China: province estimatesWeiss, John January 2008 (has links)
No description available.
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The Aid Paradigm for Poverty Reduction: Does It Make Sense?Weiss, John January 2008 (has links)
No description available.
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Testing and analysis of concrete-filled elliptical hollow sectionsYang, H., Lam, Dennis, Gardner, L. January 2008 (has links)
No description available.
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