Foreign Direct Investment is seen as a critical source of capital inflow and a stimulant of economic growth in many developing nations. It brings with it benefits such as job creation, technology and knowledge transfers just to mention a few. Thus many African countries are keen in finding ways of attracting FDI. The main objective of this paper is to empirically examine the determinants of foreign direct investment (FDI) by incorporating an econometric method based on cross-sectional data from 41 African countries over the period 2002-2007. More precisely, this research intends to answer the following question: what are the relevant determinants that promote FDI inflows in Africa? Among the several determinants of FDI, the finding suggests that market size and natural resource predominance are the main determinants of FDI into Africa.