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Effects of continuous treatment with gonadotropin-releasing hormone during the anovulatory season on gonadotropin secretion, follicular dynamics and ovulation in the mareMorton, Stephanie 17 February 2005 (has links)
Objectives were to determine if low-dose, continuous infusion of GnRH from
Fall to Spring, would prevent seasonal anovulation in mares. Twenty Quarter Horse
mares, ages 18 mo to 24 yrs, were stratified by age and body condition score and
assigned randomly to either a saline control (n = 9) or GnRH (n = 11) treatment group.
Treatments were instituted between September 23 and October 9, 2002. Gonadotropinreleasing
hormone was delivered in 0.9% physiological saline via Alzet osmotic
minipumps (Model 2004) placed sc at the base of the neck, with Silastic sham pumps
placed in control mares. Pumps were inserted on day 3 following ovulation or during the
follicular phase if ovulation had not occurred. Delivery rate of GnRH was 2.5 ug/h (60
ug/d) for the first 60 d, followed by 5.0 ug/h (120 ug/d) thereafter, with all pumps
replaced every 30 d. By December 1, all mares had become anovulatory and remained
anovulatory until February. Mean serum concentrations of LH were not affected by
treatment in anovulatory mares. In contrast, control mares that exhibited ovulatory
cycles after treatment onset had higher (P < 0.05) mean concentrations of LH during all
phases of the estrous cycle except diestrus. Mean serum concentrations of FSH were not
affected by treatment, but were lower (P < 0.05) from November though January relative
to all other months in anovulatory mares. Interovulatory intervals in mares that cycled
temporarily did not differ between groups. Ovulatory control mares had slightly larger
(P < 0.10) follicles overall than GnRH-treated mares; however, ovulatory follicle
diameters for control and GnRH-treated mares did not differ. Ovulatory control mares
had higher (P < 0.10) mean concentrations of progesterone during metestrus and late
diestrus. In a subgroup of control (n =5) and GnRH-treated (n = 5) mares, total
releasable pools of LH in response to 1 mg GnRH did not differ between groups.
Ovulation resumed in 3 control and 3 GnRH-treated mares by March 30. Results
indicate that continuous infusion of native GnRH at the doses employed herein is not
sufficient to maintain ovulatory cycles during the anovulatory season.
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Molecular cloning and characterization of gonadotropin-releasing hormone receptors in the black seabream (Mylio macrocephalus)Lee, King-yiu. January 2001 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 82-89).
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Effects of hormonal treatments, appraisal, and coping on cognitive and psychosocial functioning of men with non-localised prostate cancer /Green, Heather Joy. January 2001 (has links) (PDF)
Thesis (Ph. D.)--University of Queensland, 2001. / Includes bibliographical references.
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Interaction between positive and negative effectors of embryonic and postnatal muscle growth in the chicken and the mouseGahr, Scott Allen. January 2002 (has links)
Thesis (Ph. D.)--West Virginia University, 2002. / Title from document title page. Document formatted into pages; contains x, 157 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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Factors controlling ovarian follicular growth in sows /Bracken, Cynthia J. January 2003 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2003. / Typescript. Vita. Includes bibliographical references (leaves 141-162). Also available on the Internet.
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Factors controlling ovarian follicular growth in sowsBracken, Cynthia J. January 2003 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2003. / Typescript. Vita. Includes bibliographical references (leaves 141-162). Also available on the Internet.
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Regulation of gonadotropin-releasing hormone and gonadotropin in goldfish, carassius auratus李繼仁, Lee, Kai-yan. January 1996 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
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Inhibitory Actions of Gastrin-releasing Peptide in Mouse Anterior Cingulate CortexCao, Xiaoyan 20 March 2012 (has links)
The anterior cingulate cortex (ACC) expresses high density of Gastrin-releasing peptide (GRP) and GRP receptor mRNA. To address possible function, this investigation used patch clamp recordings in mouse brain slice preparations to evaluate intrinsic properties of ACC neurons and neuronal responses to bath-applied GRP peptide. The ACC neurons were divided according to their morphology, the properties of action potentials and their firing pattern in response to depolarizing current pulses. Two physiological groups of interneurons and three groups of pyramidal neurons were defined. Application of the GRP induced depolarization and increased firing of the interneurons while hyperpolarization and reduced firing in pyramidal neurons. Moreover, activation of GRP receptor facilitated GABAergic neurotransmission via a postsynaptic mechanism. The results suggest that GRP receptor is an important regulator of neuronal circuits in the ACC and may consequently play an important role for ACC neurons in the central processing of high brain function.
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Inhibitory Actions of Gastrin-releasing Peptide in Mouse Anterior Cingulate CortexCao, Xiaoyan 20 March 2012 (has links)
The anterior cingulate cortex (ACC) expresses high density of Gastrin-releasing peptide (GRP) and GRP receptor mRNA. To address possible function, this investigation used patch clamp recordings in mouse brain slice preparations to evaluate intrinsic properties of ACC neurons and neuronal responses to bath-applied GRP peptide. The ACC neurons were divided according to their morphology, the properties of action potentials and their firing pattern in response to depolarizing current pulses. Two physiological groups of interneurons and three groups of pyramidal neurons were defined. Application of the GRP induced depolarization and increased firing of the interneurons while hyperpolarization and reduced firing in pyramidal neurons. Moreover, activation of GRP receptor facilitated GABAergic neurotransmission via a postsynaptic mechanism. The results suggest that GRP receptor is an important regulator of neuronal circuits in the ACC and may consequently play an important role for ACC neurons in the central processing of high brain function.
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Regulation of prolactin and changes in prolactin and growth hormone in osmoregulation, metabolism, and reproduction in the tilapia, Oreochromis mossambicusWeber, Gregory Martin January 1995 (has links)
Thesis (Ph. D.)--University of Hawaii at Manoa, 1995. / Includes bibliographical references (leaves 201-220). / Microfiche. / xiii, 220 leaves, bound 29 cm
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