The object of the study was the pharmaceutical substance TRIAZID of the newest Russian antiviral drug azolo-azinovogo series containing nitro group. Objective: development and validation of the methodology for voltammetric determination of triazide in the pharmaceutical substance TRIAZID on a glassy carbon electrode. Analysis of literature data showed that in the case of biologically active nitro compounds, the most useful for quantitative determination is the electroreduction signal of the nitro group. The advantages of the signal include both the large amount of current generated per mole of the electroactive connection and the relatively low energy requirement for the reduction of the nitro group. This makes it possible to obtain a high current / concentration ratio at low recovery potentials. The conditions for obtaining an analytical signal of triazide on a glassy carbon electrode are optimized. A simple and expressive method for eliminating the interfering effect of dissolved oxygen with the help of sodium sulphite is proposed. / Объектом исследования служила фармацевтическая субстанция ТРИАЗИД новейшего российского противовирусного препарата азоло-азинового ряда, содержащего нитрогруппу. Цель работы: разработка и валидация методики вольтамперометрического определения триазида в фармацевтической субстанции ТРИАЗИД на стеклоуглеродном электроде. Анализ литературных данных показал, что в случае биологически активных нитросоединений наиболее полезным для количественного определения является сигнал электровосстановления нитрогруппы. К преимуществам сигнала можно отнести как большое количество тока, вырабатываемое на моль электроактивного соединения, так и относительно низкую потребность в энергии для восстановления нитрогруппы. Это позволяет получать высокое отношение ток / концентрация при низких потенциалах восстановления. Оптимизированы условия получения аналитического сигнала триазида на стеклоуглеродном электроде. Предложен простой и экспрессный способ устранения мешающего влияния растворенного кислорода с помощью сульфита натрия. Разработана и валидирована по актуальным требованиям Государственной Фармакопеи РФ XIII издания вольтамперометрическая методика определения триазида в фармацевтической субстанции ТРИАЗИД. Контроль содержания триазида по разработанной методике удовлетворяет заявленным критериям приемлемости, не требует дорогостоящего оборудования, привлечения высококвалифицированного персонала, отличается коротким временем анализа. При условии включения в фармстатью предприятия разработанный метод может применяться испытательными лабораториями предприятия в процессе производства препарата.

A Pipeline Analytical Program and Dredging Knowledge{Base Expert{System (DKBES) determines a pipeline dredge's production and resulting cost and schedule. Pipeline dredge engineering presents a complex and dynamic process necessary to maintain navigable waterways. Dredge engineers use pipeline engineering and slurry transport principles to determine the production rate of a pipeline dredge system. Engineers then use cost engineering factors to determine the expense of the dredge project. Previous work in engineering incorporated an object{oriented expert{system to determine cost and scheduling of mid{rise building construction where data objects represent the fundamental elements of the construction process within the program execution. A previously developed dredge cost estimating spreadsheet program which uses hydraulic engineering and slurry transport principles determines the performance metrics of a dredge pump and pipeline system. This study focuses on combining hydraulic analysis with the functionality of an expert{system to determine the performance metrics of a dredge pump and pipeline system and its resulting schedule. Field data from the U.S. Army Corps of Engineers pipeline dredge, Goetz, and several contract daily dredge reports show how accurately the DKBES can predict pipeline dredge production. Real{time dredge instrumentation data from the Goetz compares the accuracy of the Pipeline Analytical Program to actual dredge operation. Comparison of the Pipeline Analytical Program to pipeline daily dredge reports shows how accurately the Pipeline Analytical Program can predict a dredge project's schedule over several months. Both of these comparisons determine the accuracy and validity of the Pipeline Analytical Program and DKBES as they calculate the performance metrics of the pipeline dredge project. The results of the study determined that the Pipeline Analytical Program compared closely to the Goetz eld data where only pump and pipeline hydraulics a ected the dredge production. Results from the dredge projects determined the Pipeline Analytical Program underestimated actual long{term dredge production. Study results identi ed key similarities and di erences between the DKBES and spreadsheet program in terms of cost and scheduling. The study then draws conclusions based on these ndings and o ers recommendations for further use.

In this master´s thesis I am focusing on the Construction technology project of Snowboard Zezula Company. Major part of my thesis informs on a technical report for a construction technology project, a time and a financial plan of a construction, a realization study of the main technological stage, a plan of the main construction mechanism, a project of a construction site device with drawings, a financial calculation of the construction site devices and some technological rules, checking and testing plan for designed operations. Lastly I compare the two different designs of a load-bearing construction level and I calculate time of sheat removing with the economical calculation of the work fissure number.