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Antimicrobials have been instrumental in the treatment of infectious disease: responsible for worldwide infection control and reductions in disease-induced morbidity, and mortality. However, in every case where new chemotherapeutic agents have been introduced, resistance to them has eventually evolved. Principally, the current strategy for dealing with this problem is to invest heavily in drug development, with the hope that new drugs become available before all existing drugs lose their efficacy. Instead of focusing on the ‘development side’ of the problem, another possible strategy is to invest in methods of slowing evolution of resistance. We use a novel application of queueing theory to demonstrate that, when comparing equivalent changes in drug development versus evolution management, the latter has a much greater effect on ensuring a continued supply of effective antimicrobial agents. Our results therefore call for a reappraisal of the current emphasis on enhancing drug development as a means of managing resistance. / Thesis (Master, Biology) -- Queen's University, 2013-07-02 15:23:55.906

The following key words were used: resistance, change, renewal, conflict, change management, resistance management, restructuring. All economies, and especially an economy like that of The New South Africa, depend on a well-educated, adaptable and continuously teaching work force to generate and implement change and innovation in schools. This requires a high quality and standard of education. Furthermore, education has a critical role to play in attempts to develop and maintain successful democratic societies. To address these objectives, order in the practical teaching situation is a prerequisite. Educators play a key role in creating quality and order in the practical teaching situation. Quality and order in education mean that the education process and outcomes must realise the best potential of the learners and meet the expectations of the community. Other factors such as resources may also contribute, but educators are mainly responsible for such quality and order since these aspects are rooted in their knowledge, skills and dedication. At present large numbers of pupils leave school with a school record of failure and without sufficient knowledge, understanding and competence to pursue successful careers. One of the reasons for this sense of failure is the almost complete absence of order in some schools since educators are resisting change which is brought about in the education system. There are many reasons for the apparent resistance to change. It is believed that educators can, to a certain extent, be regarded as a significant factor (perhaps a key factor) causing lack of order and discipline in schools, because of lack of support from the education department in meeting the needs of educators to enable educators to be productive. The management of resistance to change by school principals in Sedibeng-West (D8) was investigated in this study. Changes are continually occurring on all levels of a rapidly developing community. The school principal, as education manager, should be trained in a firm variety of skills, whlch will enable him to implement the management of resistance to change efficiently. Examples of large-scale changes that occurred in education during the past six years are the implementation of Curriculum 2005 and the transformation of Model C schools. It would therefore appear that it might be sensible to focus on reducing educators' resistance to change as part of a strategy to re-establish and promote order in education. The aim of this research centred on the following questions: How can the concept "resistance" be interpreted to create positive attitudes amongst educators to accept change in the education system? What is the role of principals as managers of resistance to change? Firstly, a literature study was undertaken to ascertain the nature of resistance to change, as well as methods and models according to which resistance to change can be managed. Findings from the literature study point to a number of aspects of resistance to change that play a decisive role in the management of change. These include factors giving rise to resistance to change, types of resistance to change, manifestation of resistance to change and reaction phases of resistance to change. Secondly, an empirical investigation was undertaken to investigate the degree and way in which school principals manage resistance to change and how educators' attitudes can be changed to accept change positively. For this purpose structured questionnaires were used. / Thesis (M.Ed.)--North-West University, Vaal Triangle Campus, 2004.

There is evidence to suggest that inspiratory muscle training (IMT) may influence the functional properties of the muscles of the upper (UA) and lower (LA) airway. However, the nature and functional relevance of this influence is currently unclear. This thesis examined the effect of acute and chronic IMT in the context of UA and LA function. The ability of IMT to activate the UA dilator muscles, genioglossus (GG) and geniohyoid (GH), was examined using magnetic resonance imaging (MRI), as was the effect of chronic training on these muscles. In addition, the effect of acute and chronic IMT upon LA resistance (Rrs) and function was investigated in people with asthma using the Forced Oscillation Technique and conventional spirometry. For the UA, an acute bout of IMT at 60% maximal inspiratory mouth pressure (MIP) resulted in significant GG and GH activation (P < 0.001) as demonstrated by increases in the transverse relaxation time of muscle water (T2). Despite this, MRI was unable to detect any effect of chronic IMT upon UA function. For the LA, the usual increase in Rrs, following deep inhalation (DI) in people with asthma was attenuated with both single and multiple breaths against a pressure-threshold load equal to 50% MIP. However, six weeks IMT had no effect on baseline airway function or response to DI. In conclusion, an acute effect of pressure-threshold IMT upon UA and LA function was demonstrated. A strong rationale for a beneficial influence of chronic pressure-threshold IMT was therefore demonstrated. However, the data were insufficient to either reject, or accept the hypothesis that IMT exerts more than a transient influence upon UA and LA function, but insights are presented that support the need for further investigations.

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