Ambiguous loss refers to a loss that is unknown or undefined, making it difficult to cope with and resolve. Using a life course perspective that asserts that humans have agency to affect change in their own lives, this study focuses on an adoptee’s perceived ability to enact change in the situation surrounding the ambiguous loss that they may have experienced as a result of their adoption. Life course perspective also incorporates the concept of life trajectories, which explain how an early life experience can affect an individual over the course of his or her life. This study describes the essence of coping with adoption-related ambiguous loss from the viewpoint of adult adoptees.