Supply chains are considered the foundation of the global economy, and businesses with global supply chains usually encounter at least 1 disruption annually. Mitigating the negative impact of disruptions is critical to supply chain managers, as disruptions can negatively impact organizational profitability and performance. Grounded in the resource dependence theory, the purpose of this qualitative multiple case study was to explore strategies organizational and supply chain managers use to mitigate negative results from supply chain disruption. Participants were 4 supply chain managers working in 2 different international organizations located in Jordan, who used effective strategies to mitigate supply chain disruptions. Data collection involved semistructured interviews and a review of organizational documents. Data were analyzed using thematic analysis, and 2 main themes emerged: Developing relationships and collaboration and strategy to identify supply chain disruption. The implications for positive social change include the potential for organizational and supply chain managers to mitigate negative results of supply chain disruptions and improve organizational performance. Sustaining organizational performance promotes the well-being of employees, families, communities, and the economy, which can result in customer satisfaction, business growth, and stable employment.