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Factors affecting lung clearance kineticsCollier, Clare Georgina January 1990 (has links)
No description available.
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Oxygen saturation and its relationship with breathing patterns in healthy full term infants throughout their first 24 hours of lifeO'Brien, Louise Margaret January 1998 (has links)
No description available.
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The effects of prolonged hypoxia on respiration in manHoward, Luke Sebastian Geoffrey Eliot January 1995 (has links)
No description available.
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Some aspects of the ventilatory response to carbon dioxide in manCummin, Andrew R. C. January 1988 (has links)
No description available.
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Measurement of hypoxic ventilatory drive at rest and during exercise in normal manDe Cort, Susan Caroline January 1989 (has links)
No description available.
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Investigating adherence of authorised prescribers to standerd treatment guidelines/essential medicine list when treating children presenting with respiratory conditions at primary health care level in the umkhanyakude health district, Kwazulu NataHlongwana, Simangele. I. January 2013 (has links)
Thesis (MSc(Med)(Pharmacy) ) -- University of Limpopo, 2013. / Introduction: Primary Health Care (PHC) is regarded as the first level of contact with the
National Health System with health care services provided mainly by nurses with varying
competences. PHC is about interaction with people thus the quality of PHC depends
extensively on the competence of the people who provide it. Therefore, the way health care
personnel are trained and how capacity continues to be developed is of fundamental
importance to PHC. Following the Alma-Ala Declaration, policies, such as the National Drug
Policy (NDP) were developed in South Africa to guide health care services. The NDP
resulted in the formulation of Standard Treatment Guidelines/Essential Medicine List
(STGs/EML). Emphasis has been placed on all prescribers to strictly adhere to these
guidelines when providing clinical patient care. Despite these developments reports still
indicate that antibiotics are irrationally used when treating respiratory infections. It is
therefore imperative that localised reasons for deviations from the STGs/EML when treating
respiratory conditions are thoroughly investigated to facilitate relevant interventions.
Objectives: The objectives of the study were to: (1) document the treatment prescribed to
children up to 12 years of age for respiratory conditions, (2) assess adherence of the
authorised prescribers to the 2008 PHC STGs/ EML and (3) determine factors impacting on
deviations from the 2008 STGs/EML.
Method: Twenty randomly selected PHC facilities in the district participated in the study. In
each of the 20 selected PHC facilities, three prescribers were randomly selected for the
structured interview and auditing of their prescription registers. Five prescriptions from each
of the sampled prescription registers of the selected authorised prescribers, containing any
of the children's respiratory conditions to be studied, were audited. A total of 15 prescriptions
from each of the selected PHC facilities were audited. Descriptive statistics was used to
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analyse data and responses to categorical variables were summarised as frequency
counts and percentages. Results were presented as tables, figures and graphs.
Results: Pneumonia (39.7%) was found to be the most common respiratory condition seen
at Umkhanyakude Health District followed by the common cold and influenza. Amoxicillin
(52%) was the most often prescribed antibiotic for these respiratory conditions. Only 4% of
prescribers showed full adherence to the 2008 PHC STGs/EML. While prescribers had a
positive attitude towards the 2008 PHC STGs/EML, their sense of adherence, content
understanding of these guidelines, as well as knowledge of medicine used for respiratory
conditions, were exaggerated. Failure to accurately diagnose respiratory conditions and lack
of implementation and monitoring strategies were also amongst the factors impacting on
adherence.
Conclusion: Adherence to the 2008 PHC STGs/EML for the treatment of respiratory
conditions in children up to 12 years of age was found to be a challenge in Umkhanyakude
PHC facilities with only four percent of prescribers adhering to these guidelines. The
Umkhanyakude Health District Management team must consider employing multifaceted
interventions from the recommendations of this study in order to improve adherence to the
PHC STGs/EML.
Recommendations: Strategies such as intensified monitoring and evaluation, improved
supervision, targeted training and education together with compulsory in-service training are
recommended to improve adherence to the STGs/EML in the Umkhanyakude Health District.
Guideline implementation strategies with integrated approaches to guideline dissemination
must also be strengthened.
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Ethnicity, gender and cardio-respiratory functionRahman, Mohammad Atiar January 1990 (has links)
No description available.
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Automated monitoring of carbon dioxide concentration and control of airway pressure during high frequency jet ventilationSehati, Sepehr January 1990 (has links)
No description available.
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Regulation of CFTR Endocytosis by the Vasoactive Intestinal Peptide: Role of PKCεAlshafie, Walaa 02 December 2013 (has links)
The Vasoactive Intestinal Peptide (VIP) is an agonist of the CFTR chloride channel in the human airways. In the genetic disease Cystic Fibrosis, where CFTR is defective or absent from the apical membrane of epithelial cells, VIP innervations are lost. Our group has demonstrated that VIP increases CFTR membrane stability through PKCε. However, the mechanism remained to be determined. Here we found that VIP stimulation increases the interaction of NHERF1 and P-ERMs with CFTR through PKCε phosphorylation. Moreover a reduction of the interaction between intracellular CFTR and the Golgi associated protein, CAL was observed following VIP stimulation. Silencing either ERMs or NHERF1 with siRNA prevented the VIP ability to increase CFTR surface expression and function, confirming that NHERF1 and P-ERMs are necessary for VIP regulation of the sustained activity of membrane CFTR. This study shows the cellular mechanism by which prolonged VIP stimulation of airway epithelial cells regulates CFTR-dependent secretions.
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ANTICHOLINERGIC THERAPY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: NOVEL MECHANISMS OF ACTIONYoung, Aaron W. 10 1900 (has links)
<p><strong>Abstract:</strong><strong> </strong></p> <p><em>Introduction:</em></p> <p>Because the relationship between pulmonary function and exercise tolerance is highly variable in COPD, other contributing factors were investigated. Physiological factors that contribute to exercise tolerance must contribute to the symptoms limiting exercise, thus the symptoms limiting exercise in COPD and their contributing factors were explored, including an investigation of novel mechanisms to explore the reported tiotropium bromide-mediated improvement in exercise tolerance in COPD.</p> <p><em>Methods:</em></p> <p>We conducted a retrospective, cross-sectional analysis of 4,424 COPD patients and 4,221 healthy subjects; referred to McMaster University Medical Center for exercise testing. Multiple linear regression, ridge regression, and MANOVA were utilized to determine the factors contributing to exercise tolerance, important symptoms limiting exercise, and factors contributing to dyspnea.</p> <p>A randomized, double-blind, placebo-controlled, crossover study of 20 COPD subjects was performed. Repeated measures ANOVA was utilized to determine effects of 3 weeks tiotropium bromide vs. 3 weeks placebo on cardiac output and efficiency of gas exchange during exercise.</p> <p><em> </em></p> <p><em>Results:</em></p> <p>MBC, DL<sub>CO</sub>, and quadriceps strength were the three major, independent, contributors to exercise capacity (MPO = -206.3 + 5.1*Quadriceps Strength + 1.8*MBC + 10.0*DL<sub>CO</sub>, r<sup>2</sup> = 0.677). MANOVA further illustrated this.</p> <p>Dyspnea, alone or in equal combination with leg effort, was the most important symptom limiting exercise in COPD. V<sub>E</sub> and MBC were the two major, independent, contributors to dyspnea (Dyspnea = 0.95 + 0.08*V<sub>E</sub> + -0.01*MBC, r<sup>2</sup> = 0.457). The increase in dyspnea with V<sub>E</sub> was much greater than the decrease with MBC.</p> <p>Tiotropium bromide did not significantly (p = 0.72) improve the efficiency of gas exchange for oxygen, significantly worsened (p = 0.005) the efficiency of gas exchange for carbon dioxide, and did not improve cardiac output.</p> <p><em>Conclusion:</em></p> <p>We concluded the reported tiotropium bromide-mediated improvement in exercise tolerance in COPD is not mediated through improvements in gas exchange efficiency and/or cardiac output.</p> <p><strong><br /></strong></p> / Doctor of Philosophy (Medical Science)
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