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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Defining domains of the EcoK methylase by mutational analyses and DNA sequence comparisons

Kelleher, Julia E. January 1990 (has links)
No description available.
2

Essays in Animal Health Economics and Risk Communication / Essais en économie de la santé animale et la communication des risques

Tago Pacheco, Damian 19 January 2015 (has links)
Cette thèse est un effort pour améliorer la façon dont l'analyse économique est menée dans les domaines de la santé animale (chapitres 1 et 2) et la communication des risques (chapitre 3). Le chapitre 1 vise à évaluer les coûts de la politique de restriction de mouvement (MRP) au cours de l'épidémie de BTV-8 2006 en France pour les producteurs de broutards (veaux 6- 9 mois charolais sevrés (BWC)). Les producteurs de BWC représentent un secteur important de l'industrie de la viande bovine française et ils peuvent être gravement touchés par les restrictions de mouvement. Le change dans le nombre de BWC vendu lies aux restrictions de mouvement est estimé en utilisant une approche « matching » multidimensionnelle, et l'effet économique de la MRP est évalué en fonction de plusieurs scénarios qui décrivent les contraintes de capacité de fermes, le coût d'alimentation, et le prix de vente de l'animal. Les coûts associés à cette politique sont la motivation pour le chapitre 2, dans lequel le comportement stratégique des agriculteurs est incorporé dans un modèle épidémiologique Susceptible-Infectés au niveau de la ferme, tels que le MRP peut déclencher des ventes prématurées par des fermes à haut risque qui réduit significativement l'efficacité de la politique. Dans la propagation d'une maladie infectieuse, les revendeurs et les marchés de bétail fonctionnent comme des amplificateurs depuis: 1) ils sont impliqués dans des activités commerciales presque chaque semaine; 2) ils ont des transactions avec un grand nombre d'exploitations. Un raisonnement similaire est utilisé dans un cadre très différent, celui de la communication des risques. Dans le chapitre 3, un modèle utilisant des outils de réseaux sociaux est introduit pour analyser l'efficacité de différentes stratégies de communication des risques tenant en compte des contraintes budgétaires. À la fin du chapitre, les avantages de ciblage spécifique sont illustrés par rapport à les risques sanitaires de la consommation d'eau du robinet à Nogales, AZ. / This thesis is an effort to improve the way economic analysis is conducted in the fields of animal health (chapters 1 and 2) and risk communication (chapter 3). Chapter 1 aims at evaluating the costs of the movement restriction policy (MRP) during the 2006 BTV-8 epidemic in France for the producers of 6- 9 month old charolais beef weaned calves (BWC). The producers of BWC represent an important sector of the French beef industry and they can be severely affected by movement standstills. The change in the number of BWC sold that was due to the movement restrictions is estimated using a multivariate matching approach, and the economic effect of the MRP is evaluated based on several scenarios that describe farms’ capacity constraints, feeding prices, and the animal’s selling price. The costs associated to such policy are the motivation for chapter 2, in which the strategic behavior of farmers is incorporated into a susceptible-infected epidemiologic model at the farm-level, such that the MRP can trigger premature sales of high-risk farms that significantly reduce the efficacy of the policy. In the spread of an infectious disease, dealers and livestock markets work as amplifiers since: 1) they are involved in trading activities almost every single week; 2) they have transactions with a large number of farms. A similar reasoning is used in a very different framework, the one of risk communication. In chapter 3, a model using social network tools is introduced to analyze the effectiveness of different risk communication strategies under budget constraints. At the end of the chapter the benefits of specific targeting are illustrated by an application to the health risks of consuming tap water in Nogales, AZ.
3

Regulation of body weight following calorific restriction

Cameron, Kerry. January 2008 (has links)
Thesis (Ph.D.)--Aberdeen University, 2008. / Includes bibliographical references.
4

Studies of the Hae III on single-strand and duplex DNA

Neuendorf, Sandra Kay. January 1983 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1983. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
5

STRATEGIES TO IMPROVE SKELETAL MUSCLE PROTEIN TURNOVER DURING DIETARY ENERGY RESTRICTION

Hector, Amy 11 1900 (has links)
Weight loss through dietary energy restriction (ER) is an effective method to promote fat mass loss. However, a negative consequence of ER is the loss of lean body mass (LBM), particularly skeletal muscle, which is induced by an imbalance between rates of muscle protein synthesis (MPS) and muscle protein breakdown (MPB). Increased protein intake and resistance exercise (RE) during ER promote the retention of LBM. Currently, the relative contribution of MPS and MPB to diet-induced LBM loss, and the effect of protein intake and RE on these variables is not well characterized. In Study 1 we compared the acute (hour-to-hour) MPS response to the ingestion of whey and soy protein, before and after 14 days of ER (-750kcal/d). The results of Study 1 indicated that whey protein was superior to soy protein in stimulating MPS before and after ER. In Studies 2 and 3 we examined the effect of 10 days of a marked 40% energy restriction on acute postabsorptive MPS and MPB and integrated (day-to-day) MPS. Using unilateral RE, we examined the effects of protein (1.2g protein/kg/g or 2.4g protein/kg/d) at rest and in combination with resistance exercise. The results of Study 2 showed that there were no changes in acute MPB or markers of proteolysis with ER. The results of Study 3 indicated that acute and integrated MPS were reduced following ER at both protein levels (1.2g protein/kg/g or 2.4g protein/kg/d), but RE was able to prevent this decline. Taken together, these studies demonstrate that reductions in MPS are the likely reason for LBM loss during short-term dietary energy restriction, and strategies such as RE and high quality protein intake can help to prevent the decline in MPS. These findings provide information for the design of weight loss programs that wish to preserve skeletal muscle. / Thesis / Doctor of Philosophy (PhD) / Dietary energy restriction is commonly used to promote weight/fat loss; however, a potential negative consequence of dietary energy restriction is the loss of skeletal muscle mass. This thesis examines the impact of dietary energy restriction on the two processes that regulate skeletal muscle mass: muscle protein synthesis and muscle protein breakdown. Additionally, this thesis investigates the role of protein intake and resistance exercise as strategies to prevent diet-induced changes in muscle protein synthesis and breakdown. The studies within this thesis demonstrate that during energy restriction rates of muscle protein synthesis are reduced whilst muscle protein breakdown is unchanged. Importantly, consuming high quality protein such as whey protein and performing resistance exercise prevent the diet-induced decline in rates of muscle protein synthesis. These findings provide new and insightful information for the design of weight loss programs that aim to preserve skeletal muscle whilst also promoting the loss of body fat.
6

Fourier restriction phenomenon in thin sets

Papadimitropoulos, Christos January 2010 (has links)
We study the Fourier restriction phenomenon in settings where there is no underlying proper smooth subvariety. We prove an (Lp, L2) restriction theorem in general locally compact abelian groups and apply it in groups such as (Z/pLZ)n, R and locally compact ultrametric fields K. The problem of existence of Salem sets in a locally compact ultrametric field (K, | · |) is also considered. We prove that for every 0 < α < 1 and ǫ > 0 there exist a set E ⊂ K and a measure μ supported on E such that the Hausdorff dimension of E equals α and |bμ(x)| ≤ C|x|−α 2 +ǫ. We also establish the optimal extension of the Hausdorff-Young inequality in the compact ring of integers R of a locally compact ultrametric field K. We shall prove the following: For every 1 ≤ p ≤ 2 there is a Banach function space Fp(R) with σ-order continuous norm such that (i) Lp(R) ( Fp(R) ( L1(R) for every 1 < p < 2. (ii) The Fourier transform F maps Fp(R) to ℓp′ continuously. (iii) Lp(R) is continuously included in Fp(R) and Fp(R) is continuously included in L1(R). (iv) If Z is a Banach function space with the same properties as Fp(R) above, then Z is continuously included in Fp(R). (v) F1(R) = L1(R) and F2(R) = L2(R).
7

Le cadre juridique de l'investissement direct étranger en Chine / The legal framework of foreign direct investment in China

Ruan, Yehai 28 October 2013 (has links)
Depuis la réforme économique et l’ouverture de la Chine en 1978, l’économie chinoise s’est développée rapidement. Les investissements étrangers ont joué un rôle essentiel dans le développement économique chinois. La Chine est devenue la deuxième puissance économique du monde. Ce résultat positif est basé sur les avantages fiscaux aux investissements étrangers et la faiblesse du coût du travail. Aujourd’hui, ces avantages sont de moins en moins importants. Un investisseur étranger attache plus d’importance à l’environnement juridique qu’au coût du travail et aux avantages fiscaux. Suite à la perte progressive des avantages politiques et ceux du marché en Chine, la concurrence sur l’environnement de l’investissement, notamment sur l’environnement juridique de l’Etat d’accueil, va devenir une mesure importante pour attirer les investissements étrangers. Aussi l’ajustement du système du droit chinois de l’investissement est nécessaire et urgente. Le droit de l’investissement étranger contient deux aspects: la protection et la restriction de l’investissement direct étranger. Un système parfait du droit de l’investissement implique un juste équilibre entre ces deux aspects. Dans cette thèse, nous voulons nous pencher sur le droit français et le droit international afin d’analyser la relation entre la restriction et la protection de l’investissement direct étranger en droit chinois. Nous ne nous proposons pas, dans cette thèse, de recouvrir tous les domaines du droit de l’investissement en Chine. Nous entendons plutôt préciser l’influence de certains facteurs les plus importants en la matière. / Since the economic reform and opening of China in 1978, Chinese economy continued to grow at a rapid pace. Foreign investment has played an important role in China’s economic development. China has become the second largest economy in the world. This positive result is based on the tax benefits of foreign investment and low cost of labor. Today, these benefits are less important. A foreign investor attaches more importance to the legal environment than labor costs and tax benefits. Following the gradual loss of political advantage and market in China, the competition in the investment environment, including the legal environment of the host country, will become an important measure to attract foreign investment. Also adjusting the system of the Chinese investment law is necessary and urgent. The law of foreign investment has two aspects: the protection and restriction of FIE. A perfect system of investment law implies a balance between these two aspects. In this thesis, we want to study the French law and international law in order to analyze the relationship between the restriction and protection of FIE in Chinese law. We do not propose, in this thesis, covering all areas of the investment law in China. Instead, we wish to clarify the influence of some of the most important factors in the matter.
8

Homing endonuclease mechanism, structure and design /

Chevalier, Brett S. January 2002 (has links)
Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 95-109).
9

L'aspirine récapitule les caractéristiques de la restriction calorique / Aspirin recapitulates features of caloric restriction

Castoldi, Francesca 12 December 2018 (has links)
L'autophagie est un processus d'auto-digestion durant lequel les cellule dégradent leurs propres composants afin de maintenir l’homéostasie en conditions basales. L'autophagie est donc nécessaire à l’échelle de la cellule et de l’organisme car elle joue un rôle dans l’élimination des organites endommagés et des agrégats de protéines potentiellement nocifs et a la capacité de mobiliser les métabolites essentiels des réserves énergétiques en conditions de stressLa détérioration des fonctions cellulaires et au niveau de l’organisme liée à l'âge est associée à une dérégulation des voies de détection des nutriments ainsi qu’à une autophagie déficiente. La réactivation du flux autophagique peut prévenir ou améliorer ces dysfonctionnements métaboliques liés à l'âge. Les composés non toxiques capables de réduire les taux globaux d'acétylation des protéines et d'induire l'autophagie ont été classés dans la catégorie des agents mimétiques de restriction calorique (CRMs, de l’anglais « caloric restriction mimetic »). Nous montrons ici que l'aspirine et son métabolite actif, le salicylate, induisent une autophagie en raison de leur capacité à inhiber l'activité acétyltransférase de EP300. Alors que le salicylate stimule le flux autophagique dans les cellules « Wild Type », il ne permet pas d’augmenter le niveau d'autophagie dans les cellules déficientes en EP300, ni dans les cellules dans lesquelles EP300 endogène a été remplacé par les mutants EP300 résistants au salicylate. En conséquence, l'activité pro-autophagique de l'aspirine et du salicylate sur le nématode Caenorhabditis elegans est perdue lorsque l'expression de l'orthologue EP300 cpb-1 est réduite. Ces résultats permettent de conclure que l'aspirine est un CRM dont le mécanisme est conservé au cours de l’évolution. / Autophagy is a self-digestion process in which cell degrades its own components in order to maintain homeostasis in basal conditions; autophagy is required for the maintenance of cellular and organismal fitness due to its role in eliminating damaged organelles and potentially harmful protein aggregates, as well as its unique capacity to mobilize essential metabolites from complex energy stores in conditions of stress.The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysfunctions. Non-toxic compounds endowed with the capacity to reduce the overall levels of protein acetylation and to induce autophagy have been categorized as caloric restriction mimetics (CRMs). Here, we show that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300. While salicylate readily stimulates autophagic flux in control cells, it fails to further increase autophagy levels in EP300-deficient cells, as well as in cells in which endogenous EP300 has been replaced by salicylate-resistant EP300 mutants. Accordingly, the pro-autophagic activity of aspirin and salicylate on the nematode Caenorhabditis elegans is lost when the expression of the EP300 ortholog cpb-1 is reduced. Altogether, these findings identify aspirin as an evolutionary conserved CRM.
10

Influence of the maternal environment on blood pressure development in the spontaneously hypertensive rat

Gouldsborough, Ingrid January 1998 (has links)
No description available.

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