In contrast with traditional extended depth-of-field approaches, we propose a depth-based deconvolution technique that realizes the depth-variant nature of the point spread function of an ordinary fixed-focus camera. The developed technique brings a single blurred image to focus at different depth planes which can be stitched together based on a depth map to output a full-focus image. Strategies to suppress the deconvolution's ringing artifacts are implemented on three levels: block tiling to eliminate boundary artifacts, reference maps to reduce ringing initiated by sharp edges, and depth-based masking to mitigate artifacts raised by neighboring depth-transition surfaces. The performance is validated numerically for planar and multidepth objects. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)