This work is initiated from an observation of the rolling-sliding kinematic behavior observed in the motion of the knee joint. We use the slip ratio as a parameter to analyze the rolling-sliding properties of a mechanism, and also propose a method to design new mechanisms with specific slip ratio. In this research, we first verify the many definitions of the slip ratio, then modify a best definition to suit various rolling-sliding motions. Most importantly, we propose two types of rolling-sliding mechanism design. By changing the parameters of the mechanism, we can adjust its slip ratio curve to be close to a desired curve. In addition, when the idea of adjustable link length is used in the design of the mechanism, exact slip ratio curve as specified can be generated by the use of some cams.