Safety is an important aspect of ethical, socially responsible logistics. Current U.S. motor carrier (MC) safety research topical coverage includes the effects of individual and environmental influences, carrier safety management, and regulatory compliance on carrier safety and driver fatigue/safety performance. Interestingly, little research on the subject of truck drivers' safety attitudes and behaviors exists and the underlying decision-making processes that guide drivers' safety-related behaviors have received little attention. Furthermore, researchers have not provided an integrated framework that explains individual, organizational, and regulatory factors' impact on drivers' safety decision-making and performance. Truck drivers' safety judgments, decisions, and actions must adhere to societal safety norms. To that end, ethical decision-making theory that draws from the deontological and teleological traditions in moral philosophy provides a theoretical foundation and integrated framework necessary to better understand drivers' safety decision-making processes. The current research sought to determine how drivers rely on safety norms and perceived consequences in forming safety judgments and behavioral intentions. Furthermore, the study was designed to explore how various factors (i.e., individual, organizational, and regulatory) influence drivers' safety decision-making processes. Specifically, the study sought to answer the broad question, "How do commercial motor vehicle drivers make safety-related decisions, and how do individual, organizational, and regulatory factors influence drivers' safety decision-making processes?" An experimental two-factor design (2×2) was used to manipulate safety norms (i.e., "deontologically unsafe situation" and "deontologically safe situation") and consequences (i.e., "positive consequences" and "negative consequences"). Multivariate statistical analysis revealed that drivers primarily rely on deontological evaluations in forming safety judgments. Furthermore, drivers primarily relied on safety judgments when forming behavioral intentions. Drivers' attitudes toward unsafe actions and the effectiveness of driver-related safety regulations were also influential to drivers' judgments and intentions, respectively. The empirical findings demonstrate to managers that communication and education of safety norms may be highly effective to improve safety in unique occupational contexts where employees are given high levels of responsibility with little physical supervision, and where judgment errors can have devastating consequences for multiple stakeholders.