Understanding what constitutes typical adult processing of infant cues and the potential individual variations associated with it is an important early step in comprehending how caregiving practices arise. By adopting a multi-method approach, the present work aimed to enrich the knowledge on adults’ cognitive and electrophysiological responses to infant cues, by focusing on the role of the adults’ sex, the perceived quality of early care from caregivers, and the actual involvement in childcare. Four studies were presented to cover different perspectives on adults’ responses to infant cues, from cognition to electrophysiology and parental behaviors. Methodologies encompassed cognitive experimental tasks, EEG, standardized observations, and self-reported measures. Samples included non-parents, different-sex parents, and same-sex parents. Overall, the present work responded to the recent interest in understanding adults’ responses to infant cues going beyond a heteronormative perspective. Our findings reinforced the argument that differences between males and females, if present in the response to infant stimuli, might not always be biologically determined, but reinforced by societal norms. In addition, we supported the relevance of accounting for both past and current experiences of care when investigating the adults’ cognitive and electrophysiological responses to infant cues. Eventually, we started to gain some knowledge on the neurophysiological correlates of sensitive caregiving in different family contexts. On the whole, considering the complexity of plural family models, we hopefully contributed to socializing the idea that there are different ways of conceiving and understanding parenting nowadays.