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1	Phytochemical isolation of compounds from the plant sceletium tortuosum Setshedi, Itumeleng Bridgette 02 1900 (has links) Traditionally, Sceletium tortuosum has been used as a medicine and for social and spiritual purposes. The genus is distributed in the south-western parts of South Africa. This project phytochemically analysed and characterised Sceletium plant extracts and determined if any extract showed anti-malarial properties. Extracts were prepared in ethanol and methanol and various compounds were purified using column chromatography with hexane and ethyl acetate as mobile phase. The structure of isolated compounds, including mesembrine, pinitol, sucrose, mesembrenone and obtusalin, was confirmed using NMR. The Plasmodium Lactate dehydrogenase assay was used to screen all extracts and mesembrine to show that four extracts showed antimalarial activity with activity values ranging between 1.47 μg/ml and 7.32 μg/ml, well below the 10 μg/ml cut off value. The study recommends extracting compounds from fresh plant material and further research as to anti-malarial activity of compounds isolated from Sceletium tortuosum / Life & Consumer Sciences / MSc. (Life Sciences) Sceletium tortuosum Mesembryanthemaceae Traditional medicine Compound stability 615.321 Medicinal plants Traditional medicine Botanical chemistry
2	Chemotypic variation and biopharmaceutics of Sceletium tortuosum alkaloids. Shikanga, Emmanuel Amukohe. January 2012 (has links) D. Tech. Chemistry. / Aims to isolate and characterise mesembrine-type alkaloids from S. tortuosum for use as reference standards ; develop and validate analytical methods for the accurate determination of mesembrine-type alkaloids in S. tortuosum samples and commercial products for quality control purposes ; investigate inter-species variation of alkaloids in endemic Sceletium species ; establish the variation of mesembrine-type alkaloids within and between different populations of S. tortuosum specimens and hence identify various chemotypes ; determine the variations of the target alkaloids in S. tortuosum commercial products purchased from various suppliers ; determine the mesembrine-type alkaloid content of the combustion products from S. tortuosum; and to evaluate the in vitro permeation of the alkaloids across oral and intestinal mucosa. Dissertations, Academic -- South Africa. Chromatographic analysis. Alkaloids -- Quality control. Aizoaceae -- Chemotaxonomy. Drug delivery systems. Serotonin -- Antagonists. Aizoaceae -- Ethnobotany. Sceletium tortuosum.
3	Phytochemical isolation of compounds from the plant sceletium tortuosum Setshedi, Itumeleng Bridgette 11 1900 (has links) Traditionally, Sceletium tortuosum has been used as a medicine and for social and spiritual purposes. The genus is distributed in the south-western parts of South Africa. This project phytochemically analysed and characterised Sceletium plant extracts and determined if any extract showed anti-malarial properties. Extracts were prepared in ethanol and methanol and various compounds were purified using column chromatography with hexane and ethyl acetate as mobile phase. The structure of isolated compounds, including mesembrine, pinitol, sucrose, mesembrenone and obtusalin, was confirmed using NMR. The Plasmodium Lactate dehydrogenase assay was used to screen all extracts and mesembrine to show that four extracts showed antimalarial activity with activity values ranging between 1.47 μg/ml and 7.32 μg/ml, well below the 10 μg/ml cut off value. The study recommends extracting compounds from fresh plant material and further research as to anti-malarial activity of compounds isolated from Sceletium tortuosum / Life and Consumer Sciences / M. Sc. (Life Sciences) Sceletium tortuosum Mesembryanthemaceae Traditional medicine Compound stability San hunter-gatherers Traditional preparation Phytochemistry Nuclear Magnetic Resonance Obtusalin Pinitol Sucrose 615.321 Medicinal plants Traditional medicine Botanical chemistry

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