Information seeking and information avoidance are the mechanisms humans natural used for coping with uncertainties and adapting to environmental stressors. Uncertainties are rooted in knowledge gaps. In social sciences, the relationship between knowledge gaps and perceived risk have received little attention. A review of the information science literature suggests that few studies have been devoted to the investigation of the role of this relationship in motivating information-seeking behavior. As an effort to address the lack of theory building in the field of information science, this study attempts to construct a model of information seeking under risk (MISR) by examining the relationships among perceived risk, knowledge gap, fear arousal, risk propensity, personal relevance, and deprivation and interest curiosity as antecedents to motivation to seek information. An experimental approach and a scenario-based survey method are employed to design the study. Partial least square structural equation modeling (PLS-SEM) analysis was conducted to test the relationships in the proposed model. Perceived risk was found to be a highly significant predictor of information seeking in moderately high-risk situations. Similarly, personal relevant has a significant negative effect on perceived risk and its interaction with knowledge gap motivates information seeking.