The coming of knowledge-based economy age leads to the competitive advantage of high-technology industries strongly depend on human capital and intellectual capital. In order to rise the capacity of self-innovation and obtain new technologies, for high-technology industries, in-house research and development is necessary, but acquiring technology from outside, especially from academe, becomes more and more important. The phenomena of cluster, high-technology industries build factories near by universities, is the beginning of the interaction between industries and universities¡]1951 Silicon Valley¡^. Until the 1980¡¦s, the United States government didn¡¦t start to draft the policy about promoting industry-university collaboration and technology transfer, and in Taiwan, it started at 1991. Good interaction between industries and universities can arrange the resources and make a win-win situation. By reviewing the literatures on the development of scientific parks and mechanism of industry-university collaboration of Taiwan and other advanced countries¡]the United States ,Japan, and German¡^, especially focus on technology transfer, patent management, related laws, national innovation system, etc., I found some problems and defects and have some suggestions that may help.