This study is an investigation of the subject matter of eighty Italian cassone paintings of the fifteenth century now located in the United States and answers a four-part question: (1) What were the major themes pictured on cassoni panels during the Quattrocento? (2) Were the themes of cassoni in Quattrocento Italy predominantly of a religious or secular nature? (3) If secular subject matter was dominant in cassone painting, was this a reflection of the newly founded tastes of aristocratic, wealthy and middle classes? (4) Did cassoni mirror the way these classes viewed themselves and the place occupied by women in society?