Reniform nematode (Rotylenchulus reniformis Linford and Oliveira) currently infests about 36% of the Mississippi G. hirsutum acres causing economic losses of $130 million annually. For more than 40 years nematodes, including R. reniformis, have been managed using an at-planting treatment of Temik 15G or with soil fumigants like Telone II. With the label loss of Temik 15G and expense of soil fumigants, there is a need to develop an integrated nematode management program centered around nematicide seed treatments (NST) with and without foliar applications of Vydate C-LV. In addition there is a need to better understand how new cotton cultivars provide improved growth, development and yield in nematode infested fields. Results from research at Auburn and Mississippi State Universities revealed tested varieties responded positively to NST and improved growth and yield without NST was variety specific especially early in G. hirsutum development (between nodes 1-9). Cutivars Phy 499, FM 1740 and Stv 5458 showed the greatest nematode tolerance while Phy 375 WRF had the least tolerance, benefitting greatly from NST. Trials involving NST with and without Vydate C-LV indicated yield of plants treated with Temik 15G was greater than plants treated with NST treatments. Aeris + Votivo with and without Vydate C-LV provided better plant growth and yield than Aeris alone or with Vydate C-LV. Relative to yield Vydate C-LV treatments increased pounds of lint cotton/acre across all treatments. There were no differences in fruit retention at fruiting site one during the square period with fruit loss primarily occurring between bloom and open boll. Vydate C-LV treatments increased overall fruit retention compared to all nematicide seed treatments making them comparable to Temik 15G.