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The dual simplex method is frequently the most efficient technique for solving linear programming (LP) problems. This thesis describes an efficient implementation of the sequential dual simplex method and the design and development of two parallel dual simplex solvers. In serial, many advanced techniques for the (dual) simplex method are implemented, including sparse LU factorization, hyper-sparse linear system solution technique, efficient approaches to updating LU factors and sophisticated dual simplex pivoting rules. These techniques, some of which are novel, lead to serial performance which is comparable with the best public domain dual simplex solver, providing a solid foundation for the simplex parallelization. During the implementation of the sequential dual simplex solver, the study of classic LU factor update techniques leads to the development of three novel update variants. One of them is comparable to the most efficient established approach but is much simpler in terms of implementation, and the other two are specially useful for one of the parallel simplex solvers. In addition, the study of the dual simplex pivoting rules identifies and motivates further investigation of how hyper-sparsity maybe promoted. In parallel, two high performance simplex solvers are designed and developed. One approach, based on a less-known dual pivoting rule called suboptimization, exploits parallelism across multiple iterations (PAMI). The other, based on the regular dual pivoting rule, exploits purely single iteration parallelism (SIP). The performance of PAMI is comparable to a world-leading commercial simplex solver. SIP is frequently complementary to PAMI in achieving speedup when PAMI results in slowdown.

Dissertation submitted in partial compliance with the requirements for the Master's Diploma in Technology: Homoeopathy, Technikon Natal, 1994. / The purpose of the study was to determine the efficacy of simillimum treatment and Natrum muriaticum and Rhus toxicodendron on the treatment of recurrent cutaneous Herpes Simplex I with reference to patients response to treatment and patients perception of the effectiveness of treatment in order to determine the efficacy of the treatment methods in the management of recurrent Herpes Simplex I attacKS. Thirty one patients with recurrent cutaneous Herpes Simplex I were admitted to the study if they suffered from frequently recurring cutaneous Herpes Simplex lat least three times a year.Patients were recruited by means of advert ising in local newspapers, shoppi ng centres and libraries. Age group was 5-65 years. After an initial consultation including a case history and physical examination, a double-blind, random procedure ensured that the 31 patients were allocated to one of the two experimental groups.One group recei ved simillimum treatment and the other group received Natrum muriaticum and Rhus toxicodendron for a period of five months.Treatment only started at the beginning of a recurrent attaCK. At the time of recurrence details of the HSV llesion were obtained and a patient perception questionnaire / M

This thesis examines linear programming problems, the theoretical foundations of the simplex method, and how a liner programming problem can be solved with the simplex method.

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2010.

Thesis (Ph. D.)--Ohio State University, 2004. / Title from first page of PDF file. Document formatted into pages; contains xii, 208 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Deborah S. Parris, Dept. of Molecular Genetics. Includes bibliographical references (p. 191-208).

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In all bacterial, plant and animal cells, as well as in many viruses, genetic information resides in DNA (deoxyribonucleic acid). Replication of DNA is essential for proliferation, and DNA-containing viruses (such as herpesviruses) must carry out this process within the mammalian cells they infect. The enzyme ribonucleotide reductase catalyzes the first unique step leading to the production of the four deoxy-ribonucleotides used to make DNA. Each deoxyribonucleotide is produced by reduction of the corresponding ribonucleotide. After infection of a mammalian cell with herpes simplex virus (HSV) a new ribonucleotide reductase activity appears, which is distinct from the mammalian enzyme activity. This is due to induction of a separate, virally-encoded ribonucleotide reductase. Two monoclonal antibodies were raised against HSV (type 1) ribonucleotide reductase, and were found to bind but not neutralize its enzyme activity. One antibody recognized a larger (140 kD) protein and the other a smaller (40 kD) protein, suggesting the HSV 1 ribonucleotide reductase had a heterodimeric composition similar to that found in many other organisms. The 140 kD protein was sequentially degraded to 110 kD, 93 kD and 81 kD proteins by a host (Vero) cell-specific serine protease. Of these different proteolytic products, at least the 93 kD residue was enzymatically active, suggesting that part of the 140 kD protein may have functions unrelated to ribonucleotide reduction. The 140 and 40 kD proteins bound tightly to each other in a complex of the a2ß2 type, as shown by analytical glycerol gradient centrifugation. An assay system for functional small and large subunits of HSV 1 ribonucleotide reductase was developed, using two temperaturesensitive mutant viruses, defective in either the large (tsl207) or small (tsl222) subunits. Active holoenzyme was reconstituted both in vitro, by mixing extracts from cells infected with either mutant, and in vivo by coinfection of cells with both mutants. The gene encoding the small subunit of HSV 1 ribonucleotide reductase was cloned into an expression plasmid under control of a tac promoter. The recombinant protein was purified to homogeneity from extracts of transfected E. coli, and was active when combined with large subunit, as provided by extracts of tsl222- infected hamster (BHK) cells. The protein contained a novel tyrosyl free radical that spectroscopically resembled, but was distinguishable from, the active-site free radical found in either the E. coli or mammalian small subunits of ribonucleotide reductase. The gene encoding the large subunit of HSV 1 ribonucleotide reductase was also expressed in E. coli, using similar techniques. The recombinant large subunit was immunoprecipitated from extracts of transfected bacteria, and showed weak activity when combined with small subunit, provided by extracts of tsl20-infected hamster (BHK) cells. / <p>Diss. (sammanfattning) Umeå : Umeå universitet, 1989, härtill 4 uppsatser.</p> / digitalisering@umu