Indiana University-Purdue University Indianapolis (IUPUI) / Mercury (Hg) has proven to be a risk to the public, mainly through the consumption of fish. Because of this, many fish consumption advisories have been issued in Indiana. Although much is known about the global cycle of mercury, little is known about how local and regional emission sources of mercury impact local and regional mercury cycling. This study’s objective was to determine the scope of mercury concentration in central Indiana by using a broad grid of soil mercury measurements. Sampling was designed to capture the net retained mercury content in soils, and to determine whether spatial patterns in exist in soil mercury contents that could be related to emission sources of mercury and post-emission transport patterns from wind. Results from this study revealed significant differences in mercury concentrations for soils in central Indiana. The core of the study area, concentrated in the urban area of Indianapolis, exhibited soil mercury contents that were 20 times higher than values in the outskirts of the study area. The spatial pattern resembled a bulls-eye shape centered on Indianapolis, and with comparison to the reported Hg emission from local sources, including a coal-fired power plant, indicates a strong regional deposition signal linked to those emission sources but marked by wind-driven transport to the northeast. This effect of local emission sources resulting in local deposition indicates that limiting mercury emissions will have a net beneficial impact on local environmental quality and human health.