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1	The role of STAG3 in mammalian meiosis Winters, Tristan 05 March 2018 (has links) (PDF) The cohesin complex is essential for mitosis and meiosis. The specific meiotic roles of individual cohesin proteins are incompletely understood. We report in vivo functions of the only meiosis-specific STAG component of cohesin, STAG3. Newly generated STAG3-deficient mice of both sexes are sterile with meiotic arrest. In these mice, meiotic chromosome architecture is severely disrupted as no bona fide axial elements (AE) form and homologous chromosomes do not synapse. Axial element protein SYCP3 forms dot-like structures, many partially overlapping with centromeres. Asynapsis marker HORMAD1 is diffusely distributed throughout the chromatin, and SYCP1, which normally marks synapsed axes, is largely absent. Centromeric and telomeric sister chromatid cohesion are impaired. Centromere and telomere clustering occurs in the absence of STAG3, and telomere structure is not severely affected. Other cohesin proteins are present, localize throughout the STAG3-devoid chromatin, and form complexes with cohesin SMC1β. No other deficiency in a single meiosis-specific cohesin causes a phenotype as drastic as STAG3 deficiency. STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin. Meiose Spermatozyten Maus STAG3 meiosis spermatocytes mouse STAG3 ddc:610 rvk:WG 2100
2	The role of STAG3 in mammalian meiosis Winters, Tristan 21 November 2017 (has links) The cohesin complex is essential for mitosis and meiosis. The specific meiotic roles of individual cohesin proteins are incompletely understood. We report in vivo functions of the only meiosis-specific STAG component of cohesin, STAG3. Newly generated STAG3-deficient mice of both sexes are sterile with meiotic arrest. In these mice, meiotic chromosome architecture is severely disrupted as no bona fide axial elements (AE) form and homologous chromosomes do not synapse. Axial element protein SYCP3 forms dot-like structures, many partially overlapping with centromeres. Asynapsis marker HORMAD1 is diffusely distributed throughout the chromatin, and SYCP1, which normally marks synapsed axes, is largely absent. Centromeric and telomeric sister chromatid cohesion are impaired. Centromere and telomere clustering occurs in the absence of STAG3, and telomere structure is not severely affected. Other cohesin proteins are present, localize throughout the STAG3-devoid chromatin, and form complexes with cohesin SMC1β. No other deficiency in a single meiosis-specific cohesin causes a phenotype as drastic as STAG3 deficiency. STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin. info:eu-repo/classification/ddc/610 ddc:610 Meiose, Spermatozyten, Maus, STAG3 meiosis, spermatocytes, mouse, STAG3
3	Funktionelle Analyse des keimzellspezifischen Gens ADAM 27 / Functional analysis of germ cell specific gene ADAM 27 Baldauf, Christian 11 July 2011 (has links) No description available. 610 Medizin, Gesundheit Medicine ADAM 27 Infertilität knockout transgen hypoosmotischer Schwelltest Rescue-Experiment Spermatozyten-Sertolizellinteraktion ADAM 27 infertility knock out transgene hypo-osmotic swelling test rescue-experiment sperm-sertolicell-interaction 42.64 44.48 MED 301: Humangenetik

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