Thesis (Ph. D.)--University of Chicago. / "Reprinted from the Journal of comparartive neurology and psychology, vol. XVI, no. 4, 1906." Includes bibliographical references (p. 28-31). Also available on the Internet.

Thesis (Ph. D.)--University of Chicago. / Cover title. Reprinted from the Journal of comparative neurology, vol. 9, no. 2, June 1899. Bibliography: p. 107-109.

Thesis (Ph. D.)--University of Chicago. / Cover title. Reprinted from the Journal of comparative neurology, vol. 9, no. 2, June 1899. Bibliography: p. 107-109.

Repeated, intense, cutaneous stimulation results in the gradual development of inhibition of spinal interneurones. This change in neuronal activity could not be demonstrated in rats whose spinal cords had been transected, and was considered to be the consequence of supraspinal mechanisms. . Experiments sere carried out to determine which areas of the brain were involved. Unitary recordings from neurones situated in nucleus reticularis pontis-caudalis, nucleus reticularis giganto-cellularis, nucleus reticularis parvocellularis and nucleus medulla oblongata pars ventralis demonstrated a progressively increasing excitatory response to repeated intense cutaneous stimulation. These areas were shown to have direct projections to the spinal cord, by retrograde transport of horseradish peroxidase. Cells in nucleus reticularis gigantocellularis, which demonstrated a progressively increasing excitatory response, could also be antidromically activated from the spinal cord. Repeated stimulation of some of these areas produced a progressive inhibition of spinal interneurones which was similar to that resulting from cutaneous stimulation. It would appear that nucleus reticularis gigantocellularis and nucleus reticularis pontis-caudalis are involved in the development of a progressive inhibition of spinal interneurones. A similar role for other reticular and raphe nuclei can not be excluded on the basis of evidence presently available. / Medicine, Faculty of / Cellular and Physiological Sciences, Department of / Graduate

In the field of spinal-cord neurophysiology, the nature of and the rules which govern the strength of functional connections between muscle afferents and motoneurons supplying the same muscle are important to delineate. This study addressed a facet of this issue by testing the possibility that the strength of the spindle Ia-motoneuronal connections is stronger (as demonstrated by the differing amplitudes of the mean maximum composite Ia EPSPs) if both neurons supply the same sub-volume of the muscle, providing the various sub-volumes of the muscle are capable of independent action. Intracellular recordings were made of the Ia EPSP responses of semimembranosus (SM) and lateral gastrocnemius (LG) motoneurons in anesthetized low-spinal cats to electrical stimulation (Group I range) of nerve branches supplying different parts of the homonymous muscle, as well as different heteronymous muscles. For study of SM motoneurons, stimulated nerve branches included those supplying the anterior (SMa) and posterior (SMp) heads of the SM muscle and three providing heteronymous input from the anterior (BFa) and posterior (BFp) parts of biceps femoris and the distal part of the semitendinosus (STd) muscle. Ia EPSPs were partitioned such that stimulation of the SMa nerve branch produced significantly larger EPSPs in SMa motoneurons than in SMp cells; likewise, stimulation of the SMp nerve branch produced larger EPSPs in SMp motoneurons than in SMa cells. Study of the differences in the strength of heteronymous Ia input (i.e., from BFa, BFp and STd) between the SMa and SMp cell groups correlates with the different actions reported previously for the two heads of the SM muscle. For study of LG motoneurons, the stimulated nerve branches were those supplying the four neuromuscular compartments of the LG muscle (LG1, LG2, LG3 and LGm) and the nerve to a heteronymous muscle, soleus (SOL). In all five instances, partitioned Ia effects were evident. An association is suggested between the present results and previous electromyographic studies. The previous studies have shown that the muscle heads (SM) or neuromuscular compartments (LG) under consideration in this study are capable of somewhat separate actions. The present study also included assessment of the relative extent to which the partitioned Ia effects could be attributed, in part, to one or two developmental factors, topographic specificity and species specificity. The analysis suggested that both factors were potentially implicated, with species specificity somewhat predominant over topographic specificity.

Thesis (Ph. D.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 123-155).

Thesis (Ph. D.)--University of Oregon, 1999. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 63-69). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p9957571.

Thesis (doctoral)--Utrecht, 1981.

The objective of the completed research was to characterize the morphology of individual neurons within monolayer networks of fetal mouse spinal tissue via intraperikaryal injections of horseradish peroxidase (HRP). Thirty labelled neurons were reconstructed via camera lucida drawings and morphometrically analyzed.

The studies reported in this dissertation constitute the first evidence that methylprednisolone (MP) has been shown to ameliorate specific components of secondary trauma including ischemia, lactic acidosis, and lipid peroxidation.