Thesis (Ph.D.) - University of Queensland, 2004. / Includes bibliography.

Honors Project--Smith College, Northampton, Mass., 2010. / Includes bibliographical references (p. 52-65).

Thesis (M.S.)--University of Wisconsin--Madison, 1967. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1969. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.S.)--University of Delaware, 2006. / Principal faculty advisor: Leta P. Aljadir, Dept. of Health, Nutrition and Exercise. Includes bibliographical references.

Thesis (M.A.)--University of North Carolina at Chapel Hill, 2002. / Includes bibliographical references (leaves 64-66).

Thesis (Ph.D.)--Texas Christian University, 2007. / Title from dissertation title page (viewed Sept. 11, 2007). Includes abstract. Includes bibliographical references.

Made available in DSpace on 2014-06-11T19:32:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-04-02Bitstream added on 2014-06-13T18:43:56Z : No. of bitstreams: 1 conteneto_n_dr_arafo.pdf: 2202392 bytes, checksum: 01fbaf12627344e98845ce270560a0f0 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / O objetivo deste projeto foi desenvolver, em ratos, modelos experimentais de osteonecrose induzida pelos bisfosfonatos por meio da combinação de uma série de fatores de risco para esta doença, como o uso prolongado de altas doses de alendronato por via parenteral, procedimentos cirúrgicos operatórios e o estresse crônico. Os parâmetros foram estabelecidos por meio de análise histológica descritiva e por escores, análise radiográfica de alvéolos dentais, estereometria de alvéolos dentais e implantes, torque de remoção dos implantes e avaliação de marcadores do metabolismo ósseo e do estresse. No primeiro e segundo estudos foram administradas altas doses diárias ou semanais de alendronato, respectivamente, associado a exodontias dos primeiros molares inferiores. No terceiro e quarto estudos foram administradas altas doses semanais de alendronato, associado à indução de estresse crônico e instalação de implantes osseointegráveis na maxila e/ou na metáfise tibial. De um modo geral, os resultados dos estudos demonstraram que a terapia com alendronato foi associada à supressão significativa do metabolismo ósseo. Nos estudos 1 e 2, após as extrações dentais, observou-se o desenvolvimento de áreas de exposição e necrose óssea, associadas à presença de infecção significativa, especialmente na região de septo inter-dental. No estudo 3 observou-se que a indução de estresse crônico apresentou efeitos negativos sobre o metabolismo e volume do tecido ósseo neoformado nas espiras dos implantes tibiais, os quais não foram observados nos animais tratados com alendronato. Ao contrário, nestes animais, observou-se uma melhora significativa nos parâmetros de osseointegração. Já o estudo 4 demonstrou que a administração de alendronato resultou no desenvolvimento expressivo de áreas... / This study aimed to develop, in rodents, experimental models of bisphosphonatesinduced osteonecrosis through the association of several risk factors to this disease, including the long-term therapy with high dosages of alendronate by parenteral route, surgical procedures and chronic stress. The parameters were established by descriptive and scored histological analysis, radiographic evaluation of alveolar sockets, stereometry of alveolar sockets and implants, torque removal of implants and biomarkers of bone metabolism and stress. In the first and second studies, it was administered daily or weekly high doses of alendronate, respectively, associated to the lower first molar extractions. In the third and fourth studies it was administered weekly high doses of alendronate plus chronic stress induction and osseointegrated implants in the maxillae and/or tibia. In general, the outcomes of this study demonstrated that alendronate therapy was associated to a markedly bone turnover suppression. In the first and second studies, after tooth extraction, it was observed the development of exposed and necrotic bone associated to a significant infectious process, especially at the inter-radicular area. In the study three the chronic stress was related to deleterious effects on the bone metabolism and volume among tibial implants threads, which weren’t presented in animals treated with alendronate. On the contrary, in these animals, it was observed a markedly increase in the osseointegration parameters. On the other hand, the fourth study showed that the alendronate treatment resulted in the substantial development of osteonecrosis regions associated to infection at lateral areas of maxillary bone implant cavity, even with absence of exposed bone areas. In this way, we conclude that the alendronate therapy suppress significantly the bone... (Complete abstract click electronic access below)

Orientadores: Regina Celia Spadari-Bratfisch, Dora Maria Grassi-Kassisse / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-08-09T22:40:48Z (GMT). No. of bitstreams: 1 Rolim_MariaCandidaCamargo_M.pdf: 1802242 bytes, checksum: 4dd8205a065b2183624a2ba1a26b6c6c (MD5) Previous issue date: 2007 / Resumo: Estresse é a resposta do organismo a situações que representam algum tipo de ameaça à sua integridade. Acredita-se que estudantes que prestam o vestibular enfrentam um período de alto índice de estresse psicossocial que perdura durante todo o ano. Neste estudo avaliamos o índice de estresse por meio da concentração salivar de cortisol (CSC) e da ocorrência de sinais e sintomas de estresse (questionário de estresse percebido, QEP). Estes indicadores foram avaliados em alunos de um curso pré-vestibular e em alunos do segundo ano do ensino médio. A coleta de material foi realizada mensalmente ao longo do ano letivo e no dia do vestibular. Os resultados mostram que, em vestibulandos, a CSC é significativamente mais alta em setembro, mês de inscrições, quando comparada aos outros meses do ano e ao dia do exame vestibular. Neste dia, também há um aumento na CSC às 12 e às 18h, quando comparado ao mesmo horário em agosto e outubro. O QEP não variou ao longo do ano. Não houve correlação entre os indicadores fisiológicos e psicológicos de estresse, assim como entre a concentração salivar de cortisol em novembro e o índice de aprovação no exame vestibular. Em alunos do ensino médio, a CSC e o QEP não sofreram alterações significativas ao longo do ano. Nós concluímos que vestibulandos são submetidos a alto índice de estresse ao longo do ano letivo, com aumento de indicadores fisiológicos de estresse nos meses de inscrição e no momento do exame e que a CSC pode ser um indicador confiável do grau de ativação do eixo hipotála-mohipófise-adrenal e, conseqüentemente, do índice de estresse / Abstract: Stress is defined as the organism response to a variety of potentially dangerous stimulus. During the year preparing to apply for the public universities, students have enormous intellectual work and psychosocial stress including several hours of daily study. The aim of this work is to evaluate stress through the salivary cortisol levels (SC) and the ¿Perceived Stress Questionnaire¿ (PS). These indicators of stress levels were determined in volunteer students who are preparing to start university (US) and pupils in the second year of high school (HS). Saliva samples were collected once a month during the scholar year and also on the day of the exam. The SC was higher in September, when US have to decide on a career, than those seen in other months or on the day of the exam. The SC increased in the exam day at 12:00 and 18:00 o¿clock compared to August and October. The PS did not vary during the year. There was no correlation either between physiological and psychological stress or between the SC in November and the success in the admission exams. The SC and PS did not show statistical changes during the HS year. We conclude that the SC of US oscillated during the year indicating that these students are under high levels of stress, that are even higher in the period of registration and in the day of the exam, and that the SC is a good indicator of the hypothalamus-pituitary-adrenal activation level and, therefore, of stress / Mestrado / Fisiologia / Mestre em Biologia Funcional e Molecular

M.Phil. (Biokinetics) / Stress is an integral part of daily living and supports the ability to adapt. However, chronic activation without the ability to express the physical response results in overloading the physiological and psychological systems. Since urban South Africans are sedentary and experience high levels of stress, they are developing stress related chronic conditions and hypokinetic diseases (obesity, hypertension, depression). This study is aimed at decreasing the chronic physical manifestations of the stress response through somatic awareness exercise and aerobic exercise. The present investigation made use of a quantitative, comparative experimental research design over an eight-week period using pre- and post-tests. Participants were measured for psychological stress via a perceived stress scale and the chronic physical manifestations were measured via heart rate, blood pressure and body sway. The number of volunteers in the present study was 102 and they were recruited from corporate environments in the Johannesburg area. Their ages ranged from 18 to 65 years. The sample consisted of females (n = 42; % = 75) and males (n = 14; % = 25); white (n = 39; % = 69.6), black (n = 12; % = 21.4) and Indian (n = 5; % = 8.9) participants and non-smokers (n = 41; % = 73.2) and smokers (n = 15; % = 26.8). Untrained individuals were divided into 4 groups: a somatic awareness exercise (n = 9), aerobic exercise (n = 15), combination of somatic awareness and aerobic exercise group (n = 8) and a control group (n = 15). The aerobic group participated in aerobic activity, somatic awareness group in somatic awareness exercise and the combination group participated in both aerobic- and somatic awareness exercises. Individuals who trained were placed in a separate exercise group (n = 9) and had to add somatic awareness exercises to their weekly routines.