While child and adolescent depressive disorders have been historically studied as a downward extension of adult depression, recent research has supported the existence of child and adolescent depression as a distinct disorder and has indicated important developmental differences in symptomatology (Birmaher, Ryan, Williamson, Brent, & Kaufman, 1996; Lewinsohn, Hops, Roberts, Seeley, & Andrews, 1993), as well as greater intensity and endurance of depressive disorders in childhood and adolescence than in adults (Jensen, Ryan, & Prien, 1992). Continued research with adolescence is particularly necessary because such symptomatology can manifest in self destructive or even life threatening behaviors. Symptoms such as depressed mood, irritability, and diminished interest in activities can lead to cognitive, familial, and social problems (Hammen & Rudolph, 1996). There is a particular need to investigate ways to identify individuals at risk for depression, and highlighting interactions between risk factors could make this possible. Childhood and adolescent investigations have under-examined the self-schema and its possible ability to moderate the effect of negative life events on depression. The current study investigated the role of life events as an element that, when combined with distorted and negative cognitions relating to the self, would increase the existence of depressive symptomatology in adolescents. Self-schemas, life events, and interactions of both variables were examined as predictors of the severity of depressive symptomatology in 9- to 14-year old girls in two public school districts in Central Texas. Participants completed a self-report measure of depression, a projective measure of the self-schema, a self-report measure of life events, and a diagnostic interview. As expected, a negative self-schema significantly predicted level of depressive symptomatology. However, the experience of adverse life events did not predict level of depressive symptomatology. Additionally, while analyses demonstrated that adverse life events and negative self-schema together predicted the severity of depressive symptoms to a statistically significant degree, the interaction of the two independent variables did not predict severity of depressive symptoms. Implications of the results, limitations, and recommendations for future research are provided. / text

The negative relationship between economic hardship, child maltreatment, and child development in young children is well-documented. However, few studies have examined the mechanisms underlying the link between family economic hardship and child mental health outcomes in the context of child maltreatment. In this study, the family stress model is used to understand how family economic hardship affects child mental health. In this model, the effects of economic hardship on child mental health are indirect through their influence on family processes. Family processes are aspects of family life and are characterized by parental psychological functioning and parenting behavior. Because unhealthy family processes, which often lead to maltreatment, are associated with poor outcomes in the development of children, this framework can link developmental research and theory to an analysis of child maltreatment. The current study analyzes data from the National Survey of Child and Adolescent Well-Being-II, a survey of families in the child welfare system. The sample included children ages 18 months to 11 years and their parent (or caregivers). The results indicated that family income, a measure of economic hardship, was significantly associated with mental health problems in children involved in the child welfare system, but not in the way it was expected. Structural equation modeling analysis revealed no significant direct or indirect paths from family income to child mental health, but showed that family income affected other mechanisms contributing to poor child mental health. Lower family income was associated with greater parental depressive symptoms, alcohol use, drug use, and physical abuse. In line with the family stress model, the relationship between parental depression and child mental health was partially mediated through physical abuse. Similarly, physical abuse fully mediated the relationship between parental alcohol use and child mental health. However, neglect did not mediate the relationship between family processes and child mental health. Contrary to the study hypothesis, family processes did not mediate the relationship between family income and child mental health. Rather, family processes predicted poor child mental health. In particular, physical abuse was an important vehicle through which parental functioning translated to poor mental health outcomes in children. / text

Depression is one of the most common psychological disorders and may be considered as one of the most prevalent forms of emotional/psychological illness among children. The prevalence of depressive disorders tends to rise dramatically during adolescence. Cognitive diathesis-stress models maintain that depression is produced through an interaction between cognitive vulnerability and negative life events. According to Beck, core beliefs are at the core of cognitive vulnerability. After the occurrence of a negative life event, the core belief is activated and influences how the individual interprets the negative life event. Beck maintains that three core beliefs are central to the development and maintenance of depressive disorders: the belief that one is helpless, unlovable, and/or worthless. The purpose of this study was to investigate whether a coding system for a storytelling task could reliably assess Beck’s core beliefs. In doing so, this study sought to build upon previous research on the relations between negative life events, core beliefs, and depressive symptomatology among pre- and early adolescent females. Participants were 130 girls ranging in age from 9 to 14. All girls completed a self-report measure of life events and a projective story-telling measure that was used to assess their core beliefs. Participants also completed a semi-structured diagnostic interview, which served as the primary measure of depressive symptom severity. In support of previous research, both negative life events and negative core beliefs uniquely predicted the severity of depressive symptoms. Consistent with Beck’s cognitive model, the helpless and unlovable core beliefs uniquely predicted severity of depressive symptoms, although the worthless core belief did not. Further examination indicated that the helpless core belief was a more powerful influence on depressive symptoms than were the unlovable and worthless core beliefs. Contrary to Beck’s diathesis-stress model, however, negative core beliefs did not moderate the effects of negative life events on depressive symptomatology. For girls aged 9-11, however, a helpless core belief moderated the effects of negative life events on depressive symptom severity. Implications of these results, limitations, and future directions for research are discussed. / text

Muscarinic acetylcholine receptors (mAChRs) are G-protein coupled receptors that mediate various actions of Acetylcholine (ACh) in the central nervous system and peripheral nervous system. In mammals, five distinct mAChR subtypes (M1-M5) have been recognised with the M2 subtype being predominantly present in the heart. The mAChR antagonists are routinely used for the treatment of various pathophysiological conditions including respiratory conditions. However, it has been postulated that mAChR antagonists may increase morbidity and mortality in chronic obstructive pulmonary disorder (COPD) and asthma patients with underlying cardiovascular disease, raising concerns regarding the cardiovascular safety of these agents. The current study was therefore undertaken to investigate the effects of individual mAChR antagonists in the setting of myocardial ischaemia reperfusion injury and oxidative stress models. We also investigated whether the inhibition of the mitochondrial permeability transition pore (MPTP) with cyclosporine-A (CsA) in the presence and absence of individual mAChR antagonists provided protection against ischaemia reperfusion injury. Furthermore, we also aimed to investigate the intracellular signalling pathway associated with mAChRs antagonists mediated myocardial injury under the stress conditions. Langendorff results showed that the non-selective M1-M3 mAChR antagonist, ipratropium bromide, the M2 mAChR antagonist, AF-DX 116 and the M3 mAChR antagonist, DAU 5884 significantly increased the infarct size to risk ratio of the heart in conditions of ischaemia and reperfusion. Detrimental effects of AF-DX 116 and DAU 5884 were abrogated by co-treatment of these drugs with mAChR agonist, acetylcholine (ACh) and/or CsA. Cell viability data of isolated cardiac myocytes revealed that AF-DX 116 and DAU 5884 caused a concentration dependent decrease in the viability of cardiac myocytes as well as causing a reduction in the time taken to depolarisation and hypercontracture under oxidative stress. AF-DX 116 and DAU 5884 significantly increased the levels of p-SAPK/JNK and decreased the levels of p-Akt and p-ERK. In addition, ACh and CsA showed to activate p-Akt and p-ERK. To conclude, the data suggest that AF-DX 116 and DAU 5884 caused cardiotoxicity at cellular, tissue and protein level in conditions of ischaemia reperfusion injury and oxidative stress. Furthermore, inhibition of the mitochondrial transition pore with CsA protected against the AF-DX 116 and DAU 5884 induced injury via activation of the pro-survival proteins, p-Akt and p-ERK.

This study set out to explore the subjective experience of crises and life changes in the family which precede the onset of schizophrenia. The motivation for it arose from the vulnerability-stress model of schizophrenia which proposes that environmental factors such as stressful life events may help to trigger the onset or exacerbation of symptoms in people who have a genetic vulnerability for the condition. Related research suggests that crises and life changes in the family can contribute to the stress experienced by those who go on to become psychologically disturbed. This has led to an increased interest in accessing the subjective experience of schizophrenia as shared by individuals and their families through the use of narratives to provide alternative perspectives on the condition. Indeed, a growing body of evidence from research conducted with people diagnosed with schizophrenia suggests that the content of their actions and statements can be construed as meaningful and logical in the context of their family and life situations. Four individuals who had been diagnosed with schizophrenia and their families participated in this study. In each case study, two interviews were conducted, one with the individual participant and a second interview with the individual and those members of their family that were willing to attend. The interviews were guided by a semistructured interview schedule and data from the interviews was analysed using content analyses and the most prominent themes were discussed in relation to the literature. The themes in the data describe the participants’ subjective experience of the many crises and life events and change in psychological functioning that precedes the onset of florid psychotic symptoms. These findings suggest that the schizophrenic symptoms of the participants in this study helped to absorb the impact of family stressors and played a fundamental role in keeping the family systems intact. The associated behaviour appeared to sustain the roles in the family as well as long-standing patterns of interaction between the family members. The numerous interacting influences and sheer variation in the experience of just four families indicates that much still needs to be understood about the experience of schizophrenia. It is recommended that future research investigate how the subjective understanding of schizophrenia affects the lives of those affected. Copyright / Dissertation (MA)--University of Pretoria, 2009. / Psychology / unrestricted

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<p><strong>AIM </strong>People with marginalized sexual orientations experience mental health and substance use problems at a higher rate compared to heterosexuals. Experiences of discrimination have been identified as a significant factor in explaining such disparities, and a growing body of literature has developed seeking to explore the contexts in which discrimination occurs. However, one context that is understudied is the online environment. Based on Meyer’s (2003) Minority Stress Model (MSM), it is postulated that specific proximal group-specific processes mediate the relationship between discrimination and health outcomes, with other social factors providing protective effects. However, research is sparse empirically investigating different mechanisms, consequences, and potential modifying factors for sexual minority young adults experiencing online heterosexist discrimination (OHD). Thus, the current study aims to explore experiences of OHD among young adults. <strong>METHODS </strong>Using the MSM as a guiding framework, the study examined proximal factors of internalized heterosexism, online concealment, and rejection sensitivity as mechanisms underlying the effect of OHD on health outcomes and online social support as a moderating factor. 383 young adults (18-35) with marginalized sexual orientations were recruited from an introductory psychology subject pool, two online crowdsourcing platforms (Prolific, MTurk), and the community. They completed measures of OHD, online social support, online concealment, rejection sensitivity, internalized heterosexism, psychological distress, and substance use. <strong>RESULTS </strong>Path analyses in Mplus revealed that two proximal stressors (rejection sensitivity, sexual orientation concealment) were positively related to psychological distress as a result of OHD. Sexual orientation concealment was associated with increased risk for cannabis use due to OHD. Online social support from LGBTQ+ peers did not buffer these relationships. <strong>CONCLUSION </strong>The MSM is a viable guiding framework in exploring OHD. Rejection sensitivity and online sexual orientation concealment are important constructs to consider for future research and may be ideal treatment targets for individuals experiencing psychological distress or engaging in cannabis use due to OHD.</p>

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