Tissue plasminogen activator (tPA) is most effective the faster it is able to be administered to a patient that has been affected by stroke. A Stroke Code is a strategy that acute care facilities implement to reduce the time from diagnosing a stroke to administering tPA. The purpose of this study was to determine if the initiation of a Stroke Code in an acute care hospital reduces the door-to-needle time for patients affected by a stroke. In particular, does a Stroke Code reduce door-to-needle times. The research was conducted using data from April 1, 2014 to December 31, 2014 (pre-Stroke Code period) and September 1, 2015 to December 31, 2016 (post-Stroke Code period). The population of this study was treated at Holston Valley Medical Center in Kingsport, Tennessee. The analysis revealed a decrease in door-to-needle times after a Stroke Code was implemented at the acute care facility.