The overpopulation of domestic animals has become an ongoing problem across the United States. Approximately 1.5 million animals are being euthanized in the United States every year. In fact, shelters euthanize about 23 % of the animals they take in. However, the euthanasia rate would be much greater without animal rescues, which are different than animal shelters. Animal rescues are unique from shelters because they are not government-funded, and they do not usually have a physical location. Because of these factors, animal rescues rely on volunteers to care for the animals they save and donors to fund their operations. Animal rescues heavily depend on social media to fulfill many of their needs, including fundraising and volunteer recruitment, which makes the nonprofits particularly vulnerable to failure without a social media following. This research combined a content analysis of animal rescues' Facebook posts with a survey of the rescues to determine which Facebook affordances and message frames animal rescues used online were positively related to online and offline success metrics. The content analysis focused on analyzing posts for message frames, and the survey provided information about annual success. The combination of a content analysis and a survey uncovered relationships between Facebook characteristics, online message frames, and offline success metrics.