In today's world, online communication through social network services (SNSs) has become an essential aspect of people's daily lives. As social networking sites (SNSs) have become more sophisticated, cyber attackers have found ways to exploit them for harmful activities such as financial fraud, privacy violations, and sexual or labor exploitation. Thus, it is imperative to gain an understanding of these activities and develop effective countermeasures to build SNSs that can be trusted. The existing approaches have focused on discussing detection mechanisms for a particular type of online social deception (OSD) using various artificial intelligence (AI) techniques, including machine/deep learning (ML/DL) or text mining. However, fewer studies exist on the prevention and response (or mitigation) mechanisms for effective defense against OSD attacks. Further, there have been insufficient efforts to investigate the underlying intents and tactics of those OSD attackers through their in-depth understanding. This dissertation is motivated to take defense approaches to combat OSD attacks through the in-depth understanding of the psychological-social behaviors of attackers and potential victims, which can effectively guide us to take more proactive action against OSD attacks which can minimize potential damages to the potential victims as well as be cost-effective by minimizing or saving recovery cost. In this dissertation, we examine the OSD attacks mainly through two tasks, including understanding their causes and combating them in terms of prevention, detection, and mitigation. In the OSD understanding task, we investigate the intent and tactics of false informers (e.g., fake news spreaders) in propagating fake news or false information. We understand false informers' intent more accurately based on intent-related phrases from fake news contexts to decide on effective and efficient defenses (or interventions) against them. In the OSD combating task, we develop the defense systems following two sub-tasks: (1) The social capital-based friending recommendation system to guide OSN users to choose trustworthy users to defend against phishing attackers proactively; and (2) The defensive opinion update framework for OSN users to process their opinions by filtering out false information. The schemes proposed for combating OSD attacks contribute to the prevention, detection, and mitigation of OSD attacks. / Doctor of Philosophy / This Ph.D. dissertation explores the issue of online social deception (OSD) in the context of social networking services (SNSs). With the increasing sophistication of SNSs, cyber attackers have found ways to exploit them for harmful activities, such as financial fraud and privacy violations. While previous studies have focused on detection mechanisms using artificial intelligence (AI) techniques, this dissertation takes a defense approach by investigating the underlying psychological-social behaviors of attackers and potential victims. Through two tasks of understanding OSD causes and combating them through various AI approaches, this dissertation proposes a social capital-based friending recommendation system, a defensive opinion update framework, and a fake news spreaders' intent analysis framework to guide SNS users in choosing trustworthy users and filtering out phishing attackers or false information. The proposed schemes contribute to the prevention, detection, and mitigation of OSD attacks, potentially minimizing potential damages to potential victims and saving recovery costs.