Diss. (sammanfattning) Uppsala : Univ., 2003. / Härtill 4 uppsatser.

Thesis (M.S.) - - Andrews University, College of Arts and Sciences, 2008. / Bibliography: leaves 159-168.

Thesis (M.S.)--Rochester Institute of Technology, 1984. / Typescript. Includes bibliographical references (leaves 86-87).

Thesis (M.S.)--Rochester Institute of Technology, 1985. / Typescript. Includes bibliographical references (leaves 75-77).

Thesis (M.S.)--University of Missouri, School of Mines and Metallurgy, 1920. / K. K. Kershner determined to be Karl K. Kershner from "1874-1999 MSM-UMR Alumni Directory". The entire thesis text is included in file. Typescript. Illustrated by author. Title from title screen of thesis/dissertation PDF file (viewed May 25, 2009) Includes bibliographical references (p. 34-38).

Thesis (SC. D.) - University of Michigan, 1942. / Reprinted from Journal of bacteriology, vol. 47, no. 3, March, 1944. Bibliography: p. 271.

Thesis (Ph. D.)--University of Wisconsin, 1967. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M. Med. Sc.)--University of Hong Kong, 2006.

Thesis submitted for the Degree of Doctor of Medicine in the University of the Witwatersrand, Johannesburg / The interest of the biochemist in para-aminobenzoic acid is very recent and, indeed, only goes back about five years, but in this time quite a voluminous literature has accumulated on the biological aspects and importance of this aniline derivative. Attention was originally focussed on it indirectly as a result of the intensive research devoted to the understanding of the mode of action of the various sulphonamides, which were shown during the last decade to be very powerful chemothera-peutic agents against many bacteria. Fildes (1940, propounded the hypothesis that p-aminobenzoic acid was an essential meta-bolite for bacteria, that it was normally associated with an enzyme system in the bacterial cell, and that sulphanilamide, being structurally similar to p-aminobenzoic acid, was capable in sufficient concentration of displacing p-aminobenzoic acid from its enzyme and stopping this essential line of metabolism. Fildes further suggested that a substance which was found to be an essential metabolite for bacteria would also be essential in the animal kingdom, so that such a substance might be found to act as a vitamin in the higher animals and even in man. In 19U1 interest in p-aminobenzoic acid was intensified with the announcement by Ansbacher (19U1J that p-eminobenzoic acid was actually a vitamin and should be included in the vita¬min B complex. In this thesis, studies on the absorption and excretion of p-aminobenzoic acid are reported, the estimation of p-amino- bensoic acid being based on its property of antagonising the Bulphonamides. Evidence is presented that p-arainobenzoic acid la excreted ae p-acetylaminobenzoic acid, and that its conjuga- tion with the acetyl radical probably takeB place in the liver. Further it is suggested that the experiments performed do not lend support to the view that p-aminobenzolc acid is a vitamin for man. Finally the various physiological effects of p-aminobenzoic acid are discussed and an attempt is made to gauge its function in the living organism. Preliminary experiments indicating a new, hitherto unreported, role of p-aminobenzoic acid are re¬corded, namely its ability in large doses to increase the re¬sistance of animals to disease. / IT2017

The first part of this dissertation is devoted to the study of an asymmetric [3+2] cycloaddition sequence developed in our laboratory. The cycloaddition sequence used a sulfonamide-based homoenolate equivalent which was cyclocondensed with a cyclic enone. The stereochemistry of the final product was fixed during the first step, the Michael addition to the enone. Our study focused thus on the Michael addition of sulfonamides to enones. We have synthesized a series of chiral and achiral sulfonamides. We then studied the regiochemistry and the stereochemistry of the addition of the anions derived from these sulfonamides to cyclohexenone. The presence of a heteroatom at the (gamma)-carbon of the sulfonamide was crucial for the regiochemical outcome of the reaction. The substituent on the sulfonamide also influenced the facial selectivity of the reaction with chiral sulfonamides, but had no influence on the diastereoselectivity with achiral sulfonamides. The sequence had been applied to various cyclenones. We were also able to apply the method to an acyclic enone with good enantioselectivities. However the method could not be applied to other Michael acceptors. Another part of the present work was devoted to search a new catalytic asymmetric cyclopentannulation sequence. Two different approaches were studied. Phase-transfer catalysis seemed the most appropriate strategy for our objective. We soon realized that sulfur-stabilized nucleophiles could not be used under these conditions. Ketals derived from 3-nitropropanal were thus chosen as potential annulation agents. The racemic version was quite efficient and could be applied to less active acceptors such as unsaturated lactams and lactones. Unfortunately we were not able to realize the reaction with good enantioselectivities. However two new catalysts, obtained by the reaction of cinchonine with 1- and 2-methylnaphthyl chloride, emerged as interesting candidates for the phase-transfer reactions. Organocatalysis was our second approach. The use of rubidium prolinate or the use of proline in the presence of a base proved to be very efficient and the Michael adducts could be obtained with good enantioselectivities. The Michael adducts were easily cyclized and the nitro group could be removed under mild conditions.