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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The Effect of Methylphenidate (MPH) on Appetite, Energy Intake, and Body Composition in Individuals Living with Obesity: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Bani Fatemi, Shakibasadat 10 January 2019 (has links)
Objectives: This pilot study examined how Methylphenidate (MPH0.5mg/kg) affects appetite sensations, food reinforcement, energy intake (EI), macronutrient consumption, and weight-loss in youth and adults living with obesity, without ADHD. Methods: This study employed a randomized, double-blind, placebo-controlled design. Eleven participants aged 28±6.9 yrs. (4 M, 7 F) were randomized to receive either MPH (n=5) or placebo group (n=6) for 60 days. Participants’ appetite sensations (Visual Analogue Scale), relative-reinforcing value of food (computer task), EI and macronutrient consumption (ad libitum buffet), and anthropometric measurements (DEXA) were measured at baseline and 60 days. Results: Repeated measures ANOVA revealed group x time interactions for appetite sensations [desire to eat (p=0.01), hunger (p=0.002), and prospective food consumption (p=0.006)]; with greater reductions in MPH group compared to placebo. For the sense of fullness, there was an interaction between group and time (p=0.01), with a greater increase for MPH compared to placebo. Body weight significantly decreased in both groups (p=0.01), with a moderate to large effect size favouring the MPH group (-2.66 kg vs. – 1.16 kg, Cohen’s d =0.76). Changes between MPH and placebo did not differ significantly on EI, macronutrient consumption, or food reinforcement. Conclusions: Our data indicate for the first time that MPH suppresses appetite in individuals with obesity resulting in a moderate–sized effect on weight loss in the short-term. These findings warrant a larger trial to more definitively examine the effect that MPH has on weight loss and maintenance of weight loss, thereby evaluating its potential as a novel pharmacological agent in the management of obesity.

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