In hydraulics, velocity distribution is needed to determine flow characteristics, like discharge, sediment discharge, head loss, energy coefficient, moment coefficient, and scour. However, the complicated interaction between water and sediment causes great difficulties in the measurement of flow and sediment discharge. Thus, the development of a method which can simulate the velocity distribution and sediment discharge in open channels is designable. Traditional methods for the estimation of velocity distribution, such as the Prandtl-von Karman logarithmic velocity and of sediment concentration distribution, such as the Rouse equation, are generally invalid at or near the channel bed and are inaccurate at the water surface. Considering the limitations of traditional methods, entropy based models have been applied, yet the assumption on the cumulative distribution function made in these methods limits their application. The objective of this research is to develop an efficient method to estimate velocity distribution and suspended sediment discharge in open channels using the Tsallis entropy. This research focuses on a better-organized hypothesis on the cumulative probability distribution function under more applicable coordinates, which should be transformable in different dimensions. Velocity distribution and sediment distribution are derived using the Tsallis entropy under the hypothesis that the cumulative probability distribution follows a non-linear function, in which the value of the exponent is shown to be related to the width-depth ratio of channel cross-section. Three different combinations of entropy and empirical methods for velocity and sediment concentration distribution are applied to compute suspended sediment discharge. Then advantages and disadvantages of each method are discussed. The velocity distribution derived using the Tsallis entropy is expected to be easy to apply and valid throughout the whole cross-section of the open channel. This research contributes to the application of entropy theory and shows its advantages in hydraulic engineering.