Individual differences in autonomic nervous system responsiveness have been linked to a variety of physical disorders and personality and behavioral tendencies. The present study attempted to correlate specific personality characteristics hypothesized to be associated with either sympathetic or parasympathetic dominance based on the work of M. A. Wenger. The Clinical Analysis Questionnaire Personality Inventory, a physical disorders questionnaire, a self-report stress measure, and seven psychophysiologic tests were administered to 60 undergraduate students in an introductory psychology class at North Texas State University. The results provided limited support for the hypotheses. A skewed population with 50 of the 60 subjects achieving scores indicative of sympathetic dominance occurred. Statistical comparison (t-tests) of the CAQ personality traits, and clinical factor scores of these 50 subjects labeled sympathetic dominant with CAQ norms for college students revealed means on five personality traits and three clinical factors were significantly different for the sympathetic dominant group at the .05 or greater level of significance. These findings were interpreted as limited support for Wenger's work and for the positions of Acker and Kagan that individuals with more reactive sympathetic nervous systems tend to have difficulty binding anxiety, poor emotional controls and outlets, ambivalence about interpersonal relationships, and a need for group acceptance.