Sedimentary rocks in the Mecca Hills record a 3-4 Myr history of basin evolution and deformation within the southern San Andreas fault (SAF) zone. Detailed geologic mapping, measured sections, lithofacies analysis, and preliminary paleomagnetic data indicate that sedimentation and deformation in the Mecca Hills resulted from evolution of local fault zone complexities superimposed on regional subsidence and uplift. Sediment was derived from sources northeast of the SAF and transported southeast along the fault zone in large rivers, alluvial fans, and a smaller fault-bounded lake. Inversion of the Painted Canyon fault from oblique SW-side down to SW-side up slip was the main control on local deposition and deformation. Regional controls are suggested by an angular unconformity observed in the Mecca and Indio Hills along ~50 km of the SAF and synchronous post-740 ka uplift northeast of the SAF along ~80 km of the fault zone.