International Telemetering Conference Proceedings / October 20-23, 2003 / Riviera Hotel and Convention Center, Las Vegas, Nevada / Reduction of signal transmission is of paramount concern to many in the telemetry and wireless industry. One technique that is available is the compression of the data before transmission. With telemetry type data, there are many approaches that can be used to achieve compression. Data compression of the Advanced Range Telemetry (ARTM) PCM data sets in the frame and packet modes, and for the entire data file will be considered and compared. The technique of differencing data will also be applied to the data files by subtracting the previous major frame and then applying compression techniques. It will be demonstrated that telemetry compression is a viable option to reduce the amount of data to be transmitted, and hence the bandwidth. However, this compression produces variable-length data segments with implications for real-time data synchronization.